Catching up with Lyme Disease Antigenic Variation Computationally.

Catching up with Lyme Disease Antigenic Variation Computationally. Trends Microbiol. 2018 Jun 11;: Authors: Norris SJ Abstract The spirochetes that cause Lyme disease have an elaborate antigenic variation system that produces millions of variants, thus evading the immune response. Verhey et al. have applied next-generation sequencing and computational analysis to gain new insights into how these bacteria keep 'one step ahead' of elimination by the host. PMID: 29903419 [PubMed - as supplied by publisher]
Source: Trends in Microbiology - Category: Microbiology Authors: Tags: Trends Microbiol Source Type: research

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(NEW YORK) — WNBA MVP Elena Delle Donne was shocked and hurt when her request to be medically excused for the season was denied by an independent medical panel. Having battled Lyme disease for more than a decade and now taking 64 pills a day, she thought she was definitely going to be considered high-risk to get severe illness if she contracted the coronavirus. The panel of independent doctors the league and union agreed upon to make that decision thought otherwise, ruling Monday that she was not “high risk, and should be permitted to play in the bubble.” The disease is not included on the Centers for Di...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Basketball COVID-19 News Desk wire Source Type: news
This study was undertaken with the aim of a comparative and quantitative analysis of the epidemiological aspects of LD infections in Korea and Japan from 2011 to 2016. The raw data analyzed in this study were obtained from the websites of the Korea Center for Disease Control and Prevention (KCDC), Korea, and the National Institute of Infectious Diseases (NIID), Japan. In total 65 cases of LD were observed with a cumulative incidence rate (CIR) of 0.22 per million population in Korea from 2011 to 2016. During the same period in Japan, there were 75 cases of LD with a CIR of 0.10 [significantly higher than that in Korea (p
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
Her lethargy and joint pain suggested a tick-borne illness. Adding to the mystery, was a recent trip abroad a clue or a red herring?
Source: NYT Health - Category: Consumer Health News Authors: Tags: Tests (Medical) Ticks (Insects) Chikungunya Virus Lyme Disease Fatigue Diarrhea Source Type: news
Eur Neurol
Source: European Neurology - Category: Neurology Source Type: research
Publication date: December 2020Source: Interdisciplinary Neurosurgery, Volume 22Author(s): Rahul Rahangdale, Arthur Alcantara Lima, Ashis Tayal, Nitin Bhanot, Thomas Scott
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
IJERPH, Vol. 17, Pages 5105: Spatio-Temporal Dynamics of Tick-Borne Diseases in North-Central Wisconsin from 2000–2016 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17145105 Authors: Austin Rau Claudia Munoz-Zanzi Anna M. Schotthoefer Jonathan D. Oliver Jesse D. Berman Lyme disease is a well-recognized public health problem in the USA, however, other tick-borne diseases also have major public health impacts. Yet, limited research has evaluated changes in the spatial and temporal patterns of non-Lyme tick-borne diseases within endemic regions. Using laboratory dat...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Harms and colleagues advised a single dose of doxycycline to prevent Lyme disease from a Ixodes ricinus tick bite.1 Using a modified-intention-to-treat analysis, the authors that reported a single 200 mg dose of doxycycline resulted in a 67% relative risk reduction for the subjects in the treatment arm.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
We report the results of gene expression profiling via RNA-sequencing of primary human choroid plexus epithelial cells in vitro that were infected with Borrelia burgdorferi, the causative agent of Lyme disease. Epithelial cells were cultured with B. burgdorferi for 48 hours prior to RNA isolation. Following high-throughput sequencing via Illumina HiSeq 4000, a total of 258 differentially expressed genes were identified. Subsequent data analysis indicates an inflammatory and immune response generated by the epithelial cells following infection, marked by chemotactic cytokines and interferon stimulated genes. Several genes a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
The financial implications of Lyme disease (LD) can vary widely for both the health system and the individual patients experiencing the disease. The aim of this review was to summarize published data on clinic...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Review Source Type: research
We examined the effect of a positive serostatus at baseline for selected pathogens associated with chronic infections (Helicobacter pylori,Borrelia burgdorferi sensulato,Toxoplasma gondii, cytomegalovirus, Epstein-Barr virus, herpes simplex virus 1/2, and human herpesvirus 6) on all-cause mortality with multivariable parametric survival models. We found a reduced survival time in individuals with a positive serostatus forHelicobacter pylori (accelerated failure time (AFT) − 15.92, 95% CI − 29.96; − 1.88), cytomegalovirus (AFT − 22.81, 95% CI − 36.41; −&...
Source: AGE - Category: Geriatrics Source Type: research
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