Hypomethylating Agents-associated Infections —Systematic Review and Meta-analysis of Randomized Controlled Trials

Data regarding the effects of hypomethylating agents on the risk of infections are lacking. Therefore, we conducted a systematic review and meta-analysis of all randomized controlled trials comparing hypomethylating agent-containing regimens with any other regimen for patients with myeloid neoplasms. Treatment with hypomethylating agents was associated with an increase in the grade 3/4 infection rate compared with the comparator.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research