Silencing of LncRNA BDNF-AS attenuates A β25-35-induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress.

CONCLUSION: Silencing BDNF-AS exerts protective functions to increase the viability, inhibit the apoptosis and oxidative stress of Aβ25-35-induced PC12 cells by negative regulation of BDNF. ABBREVIATIONS: Aβ25-35: amyloid beta peptide 25-35; AD: Alzheimer's disease; LncRNA BDNF-AS: long non-coding RNA brain-derived neurotrophic factor anti-sense; OS: Oxidative stress. PMID: 29902125 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research