Reply to: “Strokes, cholesterol and statins: When mortality is an endpoint”

The authors generally concur with Dr. Vos and Dr. Biron [1] that long-term low cholesterol levels caused by long-term statin use might be a concern, when overall mortality or survival, is an end-point, since many prospective cohort studies have shown that a low cholesterol levels was associated with higher mortality [2 –4], and the effects of the long-term cholesterol lowering treatment have not been sufficiently investigated [5]. Clinical trials, mainly performed in men with a high risk of heart disease, have showed that statin therapy reduces all-cause mortality, almost entirely by reducing heart disease morta lity, during the follow-up period of clinical trials.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Correspondence Source Type: research