Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity.

Conclusions: The epigenetic status of the APOA2 regulatory region is associated with SFA intake and APOA2 -265T>C genotype, promoting an APOA2 expression difference between APOA2 genotypes on a high-SFA diet, and modulating BCAA and tryptophan metabolic pathways. These findings identify potential mechanisms by which this highly reproducible gene-diet interaction influences obesity risk, and contribute new insights to ongoing investigations of the relation between SFA and human health. This study was registered at clinicaltrials.gov as NCT03452787.
PMID: 29901700 [PubMed - as supplied by publisher]

Source: The American Journal of Clinical Nutrition - June 12, 2018 Category: Nutrition Authors: Lai CQ, Smith CE, Parnell LD, Lee YC, Corella D, Hopkins P, Hidalgo BA, Aslibekyan S, Province MA, Absher D, Arnett DK, Tucker KL, Ordovas JM Tags: Am J Clin Nutr Source Type: research