Early Fever after Haploidentical BMT Correlates with Class II HLA-Mismatching and Myeloablation but not Outcomes

HLA-haploidentical (haplo) transplantation is being increasingly utilized for the treatment of patients with hematologic malignancies lacking a suitable HLA-matched donor [1-4]. Recently, several groups have reported the occurrence of high fever in the absence of bacteremia, occurring between 1 and 5 days after haplo HSCT [5-10]. For example, noninfectious early fever occurred in 18 of 20 (90%) of recipients of haplo peripheral blood transplantation (PBT) after myeloablative conditioning (MAC) and post-transplant cyclophosphamide (PTCy) [7] and in 38 out of 100 (38%) of patients receiving haplo PBT with conditioning including anti-thymocyte globulin (ATG) [8].

Source: Biology of Blood and Marrow Transplantation - June 15, 2018 Category: Hematology Authors: Shannon R. McCurdy, Stephen T. Muth, Hua-Ling Tsai, Heather J. Symons, Carol Ann Huff, William H. Matsui, Ivan Borrello, Douglas E. Gladstone, Lode J. Swinnen, Kenneth R. Cooke, Robert A. Brodksy, Javier Bola ños-Meade, Richard F. Ambinder, Ravi Varadhan Source Type: research