Evaluation of radiation – Induced carotid artery stenosis after supraclavicular irradiation in patients with breast carcinoma

Conclusion Supraclavicular irradiation may play a role in the pathogenesis of carotid stenosis in about 1/3 of breast carcinoma patients. The presence of co-morbidity has an additive role in radiation induced CAS. This stresses the importance of regular examination of the carotid artery by duplex ultrasonography. Every effort should be considered to minimize the dose to carotid artery within the clinical target volume by its proper delineation especially in high risk patients.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research

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Conclusions: Our results implicate that ASCs in the tumor microenvironment actively regulate the growth of breast cancer cells through the IGF/IGFBP system.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionFurther clinical trials are necessary to improve the identification of suitable patient cohorts and the extent of possible volume de-escalation that does not compromise tumor control.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurpose of ReviewBreast Ductal Carcinoma in Situ (DCIS) is an increasingly common diagnosis and already accounts for ~20% of screen-detected breast cancers. A subset of patients with DCIS will experience disease recurrence and some will die from breast cancer. Tailored strategies for treatment are lacking at this time. Human Epidermal Growth Factor Receptor 2 (HER2) is a tumor associated antigen that is shown to correlate with poorer outcomes among patients with early breast cancer, including DCIS. Significant interactions between the humoral and cellular branches of the immune system were observed in tumorigenesis...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
ConclusionIn leukemic cells the pyrimidine catabolism induces terminal differentiation towards monocytic lineage to check the aberrant cell proliferation whereas in some solid tumors (such as triple negative breast cancer and hepatocellular carcinoma) catalytic degradation of pyrimidines maintains the mesenchymal-like state driven by epithelial to mesenchymal transition (EMT). This review further broadens this concept to understand the effect of PyM on metastasis and, ultimately, delivers a rationale to investigate the involvement of the pyrimidine molecules as oncometabolites. Overall, understanding the non-proliferative ...
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
ConclusionsIn patients with TNBC-NST, intra-E and intra-N did not correlate with pCR, but intra-E did positively correlate with tumor size. NST may exhibit a greater response to NAC, regardless of whether intra-E or intra-N is present or not on the pretreatment MRI.Key Points• Pathological complete response in TNBC-NST had no correlation with intramammary edema or intratumoral necrosis.• NAC may be justified in TNBC-NST even in the presence of edema or necrosis.• The extension of edema correlated with tumor size of TNBC-NST.
Source: European Radiology - Category: Radiology Source Type: research
In this study cytotoxicity of organotin(IV) compounds with 1,2,4-triazolo[1,5-a]pyrimidines, Me3Sn(5tpO) (1), n-Bu3Sn(5tpO) (2), Me3Sn(mtpO) (3), n-Bu3Sn(mtpO) (4), n-Bu3Sn(HtpO2) (5), Ph3Sn(HtpO2) (6) where 5HtpO = 4,5-dihydro-5-oxo-[1,2,4]triazolo-[1,5-a]pyrimidine, HmtpO = 4,7-dihydro-5-methyl-7-oxo-[1,2,4]triazolo-[1,5-a]pyrimidine, and H2tpO2 = 4,5,6,7-tetrahydro-5,7- dioxo-[1,2,4]triazolo-[1,5-a]-pyrimidine, was assessed on three different human tumor cell lines: HCT-116 (colorectal carcinoma), HepG2 (hepatocarcinoma) and MCF-7 (breast cancer). While 1 and 3 were inactive, compounds 2, 4, 5 and 6 inhibited the growth...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionsILC histology is not associated with higher risk of further metastasis at ALND in our analysis. However, surgical management decisions should be taken considering tumor histotype, biology and expected sensitivity to adjuvant therapies.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Condition:   Breast Carcinoma Interventions:   Other: Aerobic Exercise;   Other: Dietary Intervention;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Other: Resistance Training Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsBreast cancer incidence rates are increasing in most countries in both sexes, although the epidemiological features were not completely shared between FBC and MBC. More emphases should be placed on breast cancer primary prevention and the prevention strategies might need to be tailored for both FBC and MBC.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Conditions:   Anatomic Stage II Breast Cancer AJCC v8;   Anatomic Stage IIA Breast Cancer AJCC v8;   Anatomic Stage IIB Breast Cancer AJCC v8;   Anatomic Stage IIIA Breast Cancer AJCC v8;   Invasive Breast Carcinoma;   Prognostic Stage II Breast Cancer AJCC v8;   Prognost ic Stage IIA Breast Cancer AJCC v8;   Prognostic Stage IIB Breast Cancer AJCC v8;   Prognost...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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