Vitamin D reduces risk of colon cancer

According to a study, published in theJournal of the National Cancer Institute, higher vitamin D levels are associated with a lower risk of colorectal cancer, particularly in women.NBC News
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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This study evaluated the oncological outcome of surgical site infection (SSI) after colorectal cancer surgery.MethodsA total of 3675 consecutive patients with colorectal cancer who underwent curative resection from January 2009 to December 2011 were analyzed. The prognostic significance of SSI was evaluated. Risk factors for SSI were also identified using multivariate regression analysis.ResultsOverall SSI rate was 9.6%, in which 5.5% was superficial or deep SSI and 4.1% was organ/space SSI. Incidence of SSI varied significantly with tumor location (P 
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Cancers, Vol. 11, Pages 99: Opposing Regulation of Cancer Properties via KRT19-Mediated Differential Modulation of Wnt/β-Catenin/Notch Signaling in Breast and Colon Cancers Cancers doi: 10.3390/cancers11010099 Authors: Subbroto Kumar Saha Yingfu Yin Hee Sung Chae Ssang-Goo Cho Although Keratin 19 (KRT19) has been reported as a tumor cell marker and found to interact with other proteins that modulate cancer properties, its role in cancer prognosis remains to be fully elucidated. We found that KRT19 expression was increased in both colon and breast cancer, but that knockdown of KRT19 showed opposing effect...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conditions:   Metastatic Colorectal Cancer;   Stage III Colorectal Cancer Interventions:   Drug: FOLFIRI Protocol;   Other: ACTIVE SURVEILLANCE Sponsors:   Massachusetts General Hospital;   Stand Up To Cancer Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Medical College of Georgia at Augusta University) Lingering inflammation in the colon is a known risk factor for colorectal cancer and now scientists report one way it resets the stage to enable this common and often deadly cancer.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsSRHI appears to be safe and technically feasible. Moreover, SRHI reduces the length of the skin incision and postoperative pain compared with MRHE.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Authors: Yeom SS, Kim KH, Lee SY, Kim CH, Kim HR, Kim YJ Abstract Situs inversus is a rare hereditary disorder in which various anomalies have been reported with internal rotation abnormalities. This case involved an 85-year-old woman who had been diagnosed with transverse colon cancer and who underwent reduced-port laparoscopic surgery. All intra-abdominal organs were reversed left to right and right to left. The aberrant midcolic artery was identified during surgery. The total surgery time was 170 minutes, and the patient lost 20 mL of blood. The patient was discharged on the 8th postoperative day without complic...
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
In this study, we aimed to determine the predictors of disease-free survival (DFS) in patients with stage-IIIC colon cancer. METHODS: From a multicenter database, we retrospectively enrolled 611 patients (355 men and 256 women) who had undergone a potentially curative resection for a stage-IIIC colon adenocarcinoma between 2003 and 2011. The primary end-point was the 5-year DFS. RESULTS: The median age was 62 years; 213 and 398 patients had right-sided colon cancer (RCC) and left-sided colon cancer (LCC), respectively. The 5-year DFS in all patients was 52.0%; median follow-up time was 35 months (range, 1-134 month...
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Authors: Kim K, Castro EJT, Shim H, Advincula JVG, Kim YW Abstract For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occ...
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Publication date: Available online 11 January 2019Source: Cancer GeneticsAuthor(s): Kyung Kim, Su-Hye Choi, Jeeyun Lee, Won-Suk LeeAbstractColorectal cancer (CRC) is one of the leading causes of cancer-related death. We analyzed genomic of non-familial tubulovillous adenoma (TVA) and two synchronous malignant colorectal adenocarcinomas from a single patient. The number of somatic mutations was higher in the tumor sample (especially, AV50cm adenocarcinoma sample) than TVA sample, and also the allele frequency of mutation was higher on colon adenocarcinoma samples than TVA. Although they were very low frequency of sharing sa...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Núñez Carlos Villalobos Store-operated Ca2+ entry (SOCE) is the most important Ca2+ entry pathway in non-excitable cells. Colorectal cancer (CRC) shows decreased Ca2+ store content and enhanced SOCE that correlate with cancer hallmarks and are associated to remodeling of store-operated channels (SOCs). Normal colonic cells display small, Ca2+-selective currents driven by Orai1 channels. In contrast, CRC cells display larger, non-selective currents driven by Orai1 and transient receptor potential canonical type 1 channels (TRPC1). Difluoromethylornithine (DFMO), a suicide inhibitor of ornithine decarbox...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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