Vitamin D reduces risk of colon cancer

According to a study, published in theJournal of the National Cancer Institute, higher vitamin D levels are associated with a lower risk of colorectal cancer, particularly in women.NBC News
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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ConclusionsThe risk of colon cancer recurrence appears to be similar in patients with and without diabetes at diagnosis.ImpactFuture studies should evaluate the association between diabetes and colorectal cancer outcomes, especially second primary colon cancers, in larger populations.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Publication date: December 2018Source: Biomedicine &Pharmacotherapy, Volume 108Author(s): Sikang Gao, Junwu Hu, Xiongwen Wu, Zhihui LiangAbstractColon cancer is one of the most common digestive malignant tumors that leads to high mortality worldwide, and metastasis is the primary cause of cancer-related death. It is well accepted that the epithelial-mesenchymal transition (EMT) plays a key role in the process of metastasis. As a cytokine that macrophage secretes, IL-6 is involved in the progression of tumors, including the invasion and metastasis via kinds of signaling pathways. However, the mechanism of interactions b...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 21 September 2018Source: The Lancet HIVAuthor(s): Nancy A Hessol, Hannah Whittemore, Eric Vittinghoff, Ling C Hsu, Danning Ma, Susan Scheer, Sandra K SchwarczSummaryBackgroundCancer survivors are at increased risk for subsequent primary cancers. People living with HIV are at increased risk for AIDS-defining and non-AIDS-defining cancers, but little is known about their risk of first versus second primary cancers. We identified first and second primary cancers that occurred in above population expected numbers among people diagnosed with HIV in San Francisco, and compared first and second ...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
AbstractBackgroundRecent randomized trials suggest improved outcomes in patients with locally advanced colon cancer (LACC) treated with neoadjuvant chemotherapy (NAC). Optimal selection of patients for NAC depends on accurate clinical staging. The purpose of this study was to examine the degree of correlation between clinical and pathologic staging in patients with colon cancer (CC).MethodsAdult patients with non-metastatic CC who underwent surgery were identified from the National Cancer Data Base between 2006 and 2014. Data on clinical and pathologic staging was obtained. Kappa index was used to determine the correlation...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Abstract BACKGROUND: Abnormal lipid metabolism is considered to be one of main promoters of colorectal cancer (CRC), and intestinal microorganisms may be involved in CRC in patients with abnormal lipid metabolism. OBJECTIVE: To investigate lipid metabolism in CRC patients and explore the role of intestinal microorganisms in CRC complicated with abnormal lipid metabolism. METHODS: Overall, 150 CRC patients in Huzhou Central Hospital from January 2016 to September 2017 were recruited in the present study. Basic patient information and clinical serological indicators were investigated and analyzed. Twenty-o...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research
AbstractIntroductionColonic laterally spreading lesions (LSL) are increasingly managed using endoscopic methods that comprise two main techniques: endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD).Purpose of ReviewIn this review, we aimed to review the most recent literature on selection of the best endoscopic technique in the management of colonic LSL.Recent FindingsEMR and ESD are complimentary techniques in the management of patients with colonic LSL.SummaryEMR is safe and effective in most patients with LSL, except for cancers with submucosal invasion in whom R0 resection is favored.
Source: Current Treatment Options in Gastroenterology - Category: Gastroenterology Source Type: research
Colorectal Disease,Volume 0, Issue ja, -Not available-.
Source: Colorectal Disease - Category: Gastroenterology Authors: Source Type: research
Mutations in the KRAS proto-oncogene are present in 50% of all colorectal cancers and are increasingly associated with chemotherapeutic resistance to frontline biologic drugs. Accumulating evidence indicates key roles for overactive KRAS mutations in the metabolic reprogramming from oxidative phosphorylation to aerobic glycolysis in cancer cells. Here, we sought to exploit the more negative membrane potential of cancer cell mitochondria as an untapped avenue for interfering with energy metabolism in KRAS variant–containing and KRAS WT colorectal cancer cells. Mitochondrial function, intracellular ATP levels, cellular...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research
EGF ligand fused to truncated Pseudomonas aeruginosa exotoxin A specifically targets and inhibits EGFR‑positive cancer cells. Oncol Rep. 2018 Sep 06;: Authors: Hashimi SM, Grant B, Alqurashi N, Alowaidi F, Wei MQ Abstract Cancer cells have been known to overexpress the epidermal growth factor receptor (EGFR) and hence relevant multiple‑targeted therapies have been developed, with a recent clinical application of the antibody‑mediated inhibition of the EGFR. However, this strategy is not useful in cancer cells with mutations in KRAS; a GTPase downstream of EGFR which constitutively activ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Epigenetic roles of PIWI‑interacting RNAs (piRNAs) in cancer metastasis (Review). Oncol Rep. 2018 Sep 06;: Authors: Liu J, Zhang S, Cheng B Abstract P‑element‑induced wimpy testis (PIWI)‑interacting RNAs (piRNAs) are epigenetic‑related short ncRNAs that participate in chromatin regulation, transposon silencing, and modification of specific gene sites. These epigenetic factors or alterations are also involved in the growth of a variety of human cancers, including lung, breast, and colon cancer. Accumulating evidence has revealed that tumor metastasis and invasion involve genetic and epigenetic...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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