Platypus hormone could lead to new diabetes therapy

Platypus GLP-1 is more resistant to degradation and may hold the key to safer and more effective treatments for type-2 diabetes, according to research led by the University of Adelaide.Medical Xpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Researchers at University of Pennsylvania and Syracuse University found when a Type 2 diabetes drug is modified with vitamin B-12 it could reduce vomiting rates by up to 78 per cent.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionIn patients with type 2 diabetes, structural neurogenic characteristics were associated with DR. If confirmed by larger prospective studies, these results may indicate that a complex neurovascular interaction is an early event in the pathogenesis of DR.
Source: International Ophthalmology - Category: Opthalmology Source Type: research
Evidence comparing old versus new insulin analogs is poor quality. There are'many options'and'high price tags'but'little ability to discern the potential benefits of one...versus another,'said one commentator.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
Hope that observed renoprotective effects of SGLT2 inhibitors will delay worsening of kidney disease in type 2 diabetes seems to be borne out, as the CREDENCE trial is stopped early.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
Background: There are complex methods to induce type 2 diabetes as multiple low-doses streptozotocin with high fat diet administration and other combined methods which induce modest DNA damage, leading to the incomplete destruction of β cells for insulin-resistant diabetes in mice. Objective: An innovative and simple protocol was investigated to induce type 2 diabetes by only Incre-mental Multiple Low-Doses Streptozotocin (IMLDS) in mice. The effects of hydrocortisone injection on diabetes induction and pancreatic β-cells signaling were also surveyed. Method: IMLDS designed protocol was conducted in 4 consecutive...
Source: Current Chemical Biology - Category: Biochemistry Source Type: research
TUESDAY, July 17, 2018 -- Many patients with type 2 diabetes (T2D) who have a hemoglobin A1c (HbA1c) level expected to trigger treatment intensification often have treatment inappropriately delayed, according to a research letter published in the...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
DIABETES type 2 symptoms include fatigue and unexplained weight loss. But you could also be at risk of high blood sugar if you have this smelly condition, reveals ITV This Morning ’s Dr Chris Steele.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
(Society for the Study of Ingestive Behavior) Improved medications for Type 2 diabetes are one step closer thanks to a new discovery reported this week by researchers at the University of Pennsylvania and Syracuse University. By modifying the key ingredient in current diabetes drugs, the researchers produced a compound that was effective for hyperglycemia in animal trials, yet without the most problematic side effects of current drugs.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractPurpose of ReviewObesity and type 2 diabetes (T2D) are closely linked metabolic diseases. Most individuals with T2D are overweight or obese, which raises their cardiovascular risk. The etiology of both diseases is multifaceted, thus requiring a multidisciplinary approach to control them. This review describes the most effective multidisciplinary approach to weight management in patients with T2D in real-world clinical practice.Recent FindingsWeight management programs in real-world clinical settings lead to long-term weight loss for up to 5  years.SummaryMultidisciplinary approach to manage obesity and T2D thr...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
AbstractPurpose of ReviewThis review specifically summarises and reports terrestrial mammals of the gerbil subfamily, known as Israeli sand rats orPsammomys obesus (P.obesus) as a diet-controlled, unique, polygenic rodent model for research in the areas of obesity, type 2 diabetes, and cardiovascular diseases. The animal model closely mimics phenotypic and pathophysiological resemblance with human populations.Recent FindingsThe physiological status and biochemical composition inP.obesus can be manipulated effectively by controlling its nutritional intake, making it a natural model for cardiovascular and diabetic research. ...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
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