FDA Approves Moxidectin for the Treatment of River Blindness

MELBOURNE, GENEVA, and NEW YORK - June 13, 2018 -- Medicines Development for Global Health (MDGH) and the World Health Organisation Special Programme for Research and Training in Tropical Diseases (TDR) announced today that the United States (U.S.)...
Source: Drugs.com - New Drug Approvals - Category: Drugs & Pharmacology Source Type: news

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On September 5, 2002, the CEO of Merck, global health officials, and government officials from East Africa, gathered at Bombani village in the Tanga Region of Tanzania to mark 250 million doses of Mectizan having been given in Africa. This drug, manufactured and donated free by Merck, was used to combat Onchocerciasis, also known as river blindness, to prevent the loss of vision that had marked the lives of millions of Africans over generations. Globalization has often been condemned for its many shortcomings, but I was watching a miracle of globalization.
Source: Oral and Maxillofacial Surgery Clinics - Category: ENT & OMF Authors: Tags: Introduction Source Type: research
We present crystal structures of the butenolide receptor AvaR1 in is olation, and in complex with avenolide, as well as AvaR1 bound to an oligonucleotide derived from its operator. Biochemical studies guided by the co-crystal structures enable identification of 90 new actinobacteria that may be regulated by butenolides, two of which are experimentally verified. These studies provide a foundation for understanding regulation of microbial secondary metabolite production, which may be exploited for the discovery and production of novel medicines.
Source: eLife - Category: Biomedical Science Tags: Biochemistry and Chemical Biology Source Type: research
(Washington University School of Medicine) Researchers at Washington University School of Medicine in St. Louis have received two grants from the National Institutes of Health (NIH) totaling more than $5 million to study two types of parasitic worm infection that cause devastating illness in millions of people worldwide. One project will focus on onchocerciasis, commonly known as river blindness. The second project will target fascioliasis, commonly found in cattle-farming operations.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Conclusion: Features of ocular onchocerciasis usually described in forest and savanna areas were relatively less common than expected in and around Goma, the capital of the Nord Kivu province of the DRC.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Abstract Onchocerciasis is a neglected tropical disease caused by a nematode parasite, Onchocerca volvulus, and transmitted by bites of Simulium blackflies which breed near fast-flowing rivers. In humans thousands of microfilariae (immature worms) migrate to the skin and eyes where they cause pathology. Historically, much research was devoted to the serious effect of blindness, from which the disease earns its alternative name of "river blindness". Mapping the burden of onchocercal skin disease (OSD) was expedited by the development of a clinical classification and grading system which facilitated compar...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Answer toParasite Case of the Week 580:Loa loamicrofilariae. As noted by several readers, the nuclei go to the tip of the tail, the microfilariae are relatively large, and there is faint evidence of a sheath, all of which are characteristic features for this species. As I teach my students, the nuclei " flow-a flow-a " (to the tip) in Loa loa. Another memory trick from William Sears is that the nuclei go " lower and lower " in Loa loa. Take your pick for your favorite! Remember that the sheath will not always be seen. Size is a more definitive feature in differentiating Mansonella spp. from th...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
The genus Onchocerca Diesing, 1841 includes species of medical importance, such as O. volvulus (Leuckart, 1893), which causes river blindness in the tropics. Recently, zoonotic onchocercosis has been reported in ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
[This Day] Abuja -The Minister of Health, Dr. Osagie Ehanire, has said about 100 million Nigerians are currently faced with the risk of some tropical diseases such as Guinea worm, leprosy, elephantiasis, river blindness, rabies and sleeping sickness.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
(Drugs for Neglected Diseases Initiative) Over four million people will be infected with river blindness in 2025 in areas where African eye worm is present, according to new modelling.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
In the Solomon Islands, approximately 40 percent of the population of 550,000 could have active Trachoma. Credit: Catherine Wilson/IPS.By Ifeanyi NsoforABUJA, Aug 19 2019 (IPS) Recently, the World Health Organisation (WHO) launched global consultations for a new Roadmap on how to eliminate Neglected Tropical Diseases (NTDs). The roadmap would help achieve universal health coverage by 2030, address health emergencies and promote healthier populations. This intervention is unprecedented because it could begin to reverse the neglect and inequities that the 17 main NTDs bring. Many NTDs are debilitating and red...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Global Headlines Health Source Type: news
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