Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats.

CONCLUSIONS: Enhancement of mitochondrial oxidative stress in the diabetic kidney was mediated by the reduction of Sirt3 activity. CD38 overexpression may be related to a reduction in the NAD+/NADH ratio in the diabetic kidney.
PMID: 29897845 [PubMed - in process]

Source: Redox Report : communications in free radical research - June 15, 2018 Category: Biochemistry Authors: Ogura Y, Kitada M, Monno I, Kanasaki K, Watanabe A, Koya D Tags: Redox Rep Source Type: research