Kerala watches for deadly Nipah virus
Publication date: 9 June 2018 Source:New Scientist, Volume 238, Issue 3181
Authors: Thulaseedaran NK, Kumar KGS, Kumar J, Geetha P, Jayachandran NV, Kamalasanan CG, Mathew S, Pv S Abstract During May 2018 there occurred an outbreak in Kerala, which started in Soopikkada Village, Changarothu Grama Panchayath in Perambra Taluk, Kozhikode district, of a febrile illness with altered sensorium and ARDS. The diagnosis was made from the second case that it is the dreaded nipah infection. Following that 18 cases tested positive for nipah virus infection of which 2 survived. Also there were four deaths with similar clinical picture but which occurred before the virus was identified. They were cons...
Authors: Av R, Sadanandan S, Thulaseedharan NK, Kg SK, Pallivalappil B, As AK Abstract Nipah Virus Infection is an emerging zoonotic infection which presents with acute encephalitis and respiratory distress syndrome. It is associated with high mortality and classified as Biosafety level 4 organisms in view of its features which make it a potential agent for Bioterrorism. Experience with broad spectrum antiviral agent Ribavirin is promising in reducing the mortality and morbidity. PMID: 31313551 [PubMed - in process]
Isolating adults with respiratory symptoms resulting from Nipah virus infection may help stem the spread of the virus, a New England Journal of Medicinestudy suggests.
This article reviews what has been learned from biochemical and structural studies on the VSV RNA biosynthesis machinery, and then focuses on recent advances in our understanding of regulatory and catalytic roles of the PRNTase domain in RNA synthesis and capping.
Findings help guide surveillance to prevent disease outbreaks More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=298814&WT.mc_id=USNSF_1 This is a Research News item.
(Cary Institute of Ecosystem Studies) Since its discovery in 1999, Nipah virus has been reported almost yearly in Southeast Asia, with Bangladesh and India being the hardest hit. In a new study, published today in PLoS Neglected Tropical Diseases, scientists used machine learning to identify bat species with the potential to host Nipah virus, with a focus on India -- the site of a 2018 outbreak. Four new bat species were flagged as surveillance priorities.
by Raina K. Plowright, Daniel J. Becker, Daniel E. Crowley, Alex D. Washburne, Tao Huang, P. O. Nameer, Emily S. Gurley, Barbara A. Han The 2018 outbreak of Nipah virus in Kerala, India, highlights the need for global surveillance of henipaviruses in bats, which are the reservoir hosts for this and other viruses. Nipah virus, an emerging paramyxovirus in the genusHenipavirus, causes severe disease and stuttering chains of transmission in humans and is considered a potential pandemic threat. In May 2018, an outbreak of Nipah virus began in Kerala,> 1800 km from the sites of previous outbreaks in eastern India in 2001 an...
Authors: Ochani RK, Batra S, Shaikh A, Asad A Abstract The Nipah virus was discovered twenty years ago, and there is considerable information available regarding the specificities surrounding this virus such as transmission, pathogenesis and genome. Belonging to the Henipavirus genus, this virus can cause fever, encephalitis and respiratory disorders. The first cases were reported in Malaysia and Singapore in 1998, when affected individuals presented with severe febrile encephalitis. Since then, much has been identified about this virus. These single-stranded RNA viruses gain entry into target cells via a process k...
by Neeltje van Doremalen, Teresa Lambe, Sarah Sebastian, Trenton Bushmaker, Robert Fischer, Friederike Feldmann, Elaine Haddock, Michael Letko, Victoria A. Avanzato, Ilona Rissanen, Rachel LaCasse, Dana Scott, Thomas A. Bowden, Sarah Gilbert, Vincent Munster Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiVB, a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syrian hamsters. Prime-only as well as prime-boost vaccination resulted i...
India has put more than 300 people under surveillance after a 23-year-old man was diagnosed with the Nipah virus, a rare and often deadly disease.
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