The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

This study demonstrates the therapeutic potential for targeting DOT1L in MLL-r leukemia and lays the groundwork for future combination approaches in this patient population. This clinical trial is registered at www.clinicaltrials.gov as NCT01684150.

Source: Blood - June 14, 2018 Category: Hematology Authors: Stein, E. M., Garcia-Manero, G., Rizzieri, D. A., Tibes, R., Berdeja, J. G., Savona, M. R., Jongen-Lavrenic, M., Altman, J. K., Thomson, B., Blakemore, S. J., Daigle, S. R., Waters, N. J., Suttle, A. B., Clawson, A., Pollock, R., Krivtsov, A., Armstrong, Tags: Myeloid Neoplasia, Clinical Trials and Observations Source Type: research