Response to “Infantile-onset deafness in m.7445A > G carriers may be multicausal ”

We would like to thank Dr. Josef Finsterer and Dr. Zarrouk-Mahjoub for their insightful and constructive comments on our study [1]. At first, m.7445A>G heteroplasmy rates reported by Tranah et al. was based on the analysis on platelets [2] and our study was based on the analysis on whole blood cells. Thus, the heteroplasmy rates of the two studies cannot be compared because heteroplasmy rates are various in various organs in cases with mitochondrial diseases [3,4].
Source: International Journal of Pediatric Otorhinolaryngology - Category: ENT & OMF Authors: Tags: Letter to the Editor Source Type: research