Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats

Calcium/calmodulin-dependent kinase II-delta (CaMKII δ) activity is enhanced during hyperglycemia and has been shown to alter intracellular calcium handling in cardiomyocytes, ultimately leading to reduced card...

Source: Cardiovascular Diabetology - June 14, 2018 Category: Cardiology Authors: Lorna J. Daniels, Rachel S. Wallace, Olivia M. Nicholson, Genevieve A. Wilson, Fiona J. McDonald, Peter P. Jones, J. Chris Baldi, Regis R. Lamberts and Jeffrey R. Erickson Tags: Original investigation Source Type: research