A multi-organ loss of tissue phenotype in COPD: involvement of the functional muscle-bone unit

In the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) chronic obstructive pulmonary disease (COPD) cohort including 1817 men and women aged 40–75 years with full computed tomography (CT) data, Celli et al. [1] showed that emphysema progression was associated with loss of extrapulmonary tissues such as skeletal muscle and bone. I agree with the authors that identification of the patients they proposed to name a multi-organ loss of tissue (MOLT) COPD phenotype is important because of worse clinical outcomes [1] and would also like to point out that physical activity plays a significant role in the association.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research