African-American race and mortality in interstitial lung disease: a multicentre propensity-matched analysis
We studied whether African-American race is associated with younger age and decreased survival time at diagnosis of interstitial lung disease (ILD).
We performed a multicentre, propensity score-matched analysis of patients with an ILD diagnosis followed at five US hospitals between 2006 and 2016. African-Americans were matched with patients of other races based on a time-dependent propensity score calculated from multiple patient, physiological, diagnostic and hospital characteristics. Multivariable logistic regression models were used. All-cause mortality and hospitalisations were compared between race-stratified patient cohorts with ILD, and sensitivity analyses were performed.
The study included 1640 patients with ILD, 13% of whom were African-American, followed over 5041 person-years. When compared with patients of other races, African-Americans with ILD were younger at diagnosis (56 years versus 67 years), but in the propensity-matched analyses had greater survival (hazard ratio 0.46, 95% CI 0.28–0.77; p=0.003) despite similar risk of respiratory hospitalisations (relative risk 1.04, 95% CI 0.83–1.31; p=0.709), and similar GAP-ILD (gender–age–physiology-ILD) scores at study entry. Sensitivity analyses in a separate cohort of 9503 patients with code-based ILD diagnosis demonstrated a similar association of baseline demographic characteristics with all-cause mortality.
We conclude that African-Americans demonstrate a unique phenotype ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Adegunsoye, A., Oldham, J. M., Bellam, S. K., Chung, J. H., Chung, P. A., Biblowitz, K. M., Montner, S., Lee, C., Hsu, S., Husain, A. N., Vij, R., Mutlu, G., Noth, I., Churpek, M. M., Strek, M. E. Tags: Interstitial and orphan lung disease Original Articles: Interstitial lung diseases Source Type: research