Relapsing Remitting Multiple Sclerosis and its Relationship with the Immune System and Oxidative Stress

Conclusion: Dietary intake of PUFAs and melatonin could also be considered as adjuvant treatments for that clinical course of relapsing-recurrent multiple sclerosis. Further studies focusing on the role of endocannabinoids derived from PUFA´s in MS are needed.
Source: Current Immunology Reviews - Category: Allergy & Immunology Source Type: research

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The objective of this study was to evaluate the effect of a rehabilitation program in changing the perception of fatigue in patients with multiple sclerosis. MATERIAL AND METHODS The study involved 65 respondents/patients with clinically confirmed multiple sclerosis (54 women, 11 men, average age 46.49 years). The evaluation of the effects of fatigue on the physical, psychological, and psychosocial aspects of life was assessed using the Modified Fatigue Impact Scale (MFIS). To test the effectiveness of the neurorehabilitation program, we enrolled 2 groups: the experimental group (EG, n=32, 29 women, 3 men, Expanded Disabil...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
King Exley Multiple sclerosis (MS) is a devastating and debilitating neurodegenerative disease of unknown cause. A consensus suggests the involvement of both genetic and environmental factors of which the latter may involve human exposure to aluminium. There are no data on the content and distribution of aluminium in human brain tissue in MS. The aluminium content of brain tissue from 14 donors with a diagnosis of MS was determined by transversely heated graphite furnace atomic absorption spectrometry. The location of aluminium in the brain tissue of two donors was investigated by aluminium-specific fluorescence mi...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
This article discusses the pathophysiology and clinical findings associated with each of the most common causes of upper extremity spasticity.
Source: Hand Clinics - Category: Orthopaedics Authors: Source Type: research
This study examined the associations between gait variability based on common spatiotemporal parameters and energetic cost of walking in persons with multiple sclerosis. Design Eighty-six persons with multiple sclerosis underwent the 6-min walk while wearing a portable metabolic unit. The cost of walking was generated by dividing the net steady-state VO2 (milliliter per kilogram per minute) by walking speed during the 6-min walk. Participants further completed two trials of walking on the GAITRite mat at a self-selected pace for measuring spatiotemporal parameters. Variability of step length, step time, stride length, s...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
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Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Invited Commentary Source Type: research
Conclusions: This study showed that retinal axonal and neuronal loss is present among collision sport athletes, with most notable differences seen in boxers. These findings are accompanied by reductions in visual function and QOL, similar to patterns observed in multiple sclerosis, Alzheimer and Parkinson diseases. Vision-based changes associated with head trauma exposure that have the potential to be detected in vivo represent a unique opportunity for further study to determine if these changes in collision sport athletes are predictive of future neurodegeneration.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Original Contribution Source Type: research
From the Section Editor: The next two installments in the JNO “Disease of the Year: Multiple Sclerosis” series focus on lessons that can be learned form the afferent visual pathway, as a putative model of MS. In their article entitled, “Visual evoked potentials as a biomarker in multiple sclerosis and associated optic neuritis” Leocani and colleagues highlight the role of visual evoked potential (VEP) testing as a means of capturing the effects of demyelination, remyelination, and associated neuroaxonal injury in the central nervous system (CNS). Conjointly, Horton and Bennett discuss the acute mana...
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Disease of the Year: Multiple Sclerosis Source Type: research
Abstract: The current management of acute optic neuritis (ON) is focused on expediting visual recovery through the use of high-dose intravenous corticosteroids. The recent identification of specific autoantibodies associated with central nervous system inflammatory disorders has provided novel insights into immune targets and mechanisms that impact the prognosis, treatment, and recurrence of ON. Therefore, neurologists and ophthalmologists need to be aware of clinical, laboratory, and imaging findings that may provide important clues to the etiology of ON and the potential need for aggressive management. Moving forward, ...
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Disease of the Year: Multiple Sclerosis Source Type: research
In this issue of JNO, Drs. M. Tariq Bhatti and Mark L. Moster discuss the following 6 articles: 1. Hitomi E, Simpkins AN, Luby M, Latour LL, Leigh RJ, Leigh R. Blood-ocular barrier disruption in patients with acute stroke. Neurology. 2018;90:e915–e923.2. Karaa A, Haas R, Goldstein A, Vockley J, Weaver WD, Cohen BH. Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy. Neurology. 2018;90:e1212–e1221.3. Maggi P, Absinta M, Grammatico M, Vuolo L, Emmi G, Carlucci G, Spagni G, Barilaro A, Repice AM, Emmi L, Prisco D, Martinelli V, Scotti R, Sadeghi N, Perrotta G, Sati P, D...
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Literature Commentary: PDF Only Source Type: research
Publication date: Available online 17 August 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Ridvan Aktan, Sevgi Ozalevli, Serkan OzakbasAbstractObjectiveThe aim of the study was to investigate the effects of smoking on respiratory symptoms and functional levels by questioning use of cigarette in Multiple Sclerosis (MS) patients.MethodsA questionnaire was sent via e-mail to the 135 MS patients, who clinically diagnosed with MS and EDSS score was determined.Perceived dyspnea was assessed by the mMRC scale.The severity of dyspnea and fatigue perceived during rest and effort was assessed by the mBORG scale.Func...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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