Relapsing Remitting Multiple Sclerosis and its Relationship with the Immune System and Oxidative Stress

Conclusion: Dietary intake of PUFAs and melatonin could also be considered as adjuvant treatments for that clinical course of relapsing-recurrent multiple sclerosis. Further studies focusing on the role of endocannabinoids derived from PUFA´s in MS are needed.
Source: Current Immunology Reviews - Category: Allergy & Immunology Source Type: research

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Conditions:   Multiple Sclerosis;   Rehabilitation Interventions:   Device: Robot assisted treatment (Amadeo®);   Other: Conventional treatment Sponsor:   Universita di Verona Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Carlos R. Camara-Lemarroy, Luanne Metz, Eric E. Smith, Jeff F. Dunn, V. Wee Yong
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Fahimeh Safaeinejad, Soheyl Bahrami, Heinz Redl, Hassan Niknejad
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: Our study revealed that changes of RANKL/RANK/OPG axis are associated with MS, particularly the decreased OPG level in the CSF at disease onset. Therefore, these factors may serve as disease biomarkers and molecular targets of novel therapeutic approaches.Neuroimmunomodulation
Source: Neuroimmunomodulation - Category: Allergy & Immunology Source Type: research
(Karolinska Institutet) While the DNA sequence remains the same throughout a person's life, the expression of the encoded genes may change with time and contribute to disease development in genetically predisposed individuals. Researchers at Karolinska Institutet have now discovered a new mechanism of a major risk gene for multiple sclerosis (MS) that triggers disease through epigenetic regulation. They also found a protective genetic variant that reduces the risk for MS. The study is published in Nature Communications.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This article provides a review of established and novel techniques to measure the anterior visual system in multiple sclerosis with a focus on the evidence to support their use as outcome measures in clinical trials focused on neuroprotection and remyelination therapies.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
AbstractPurpose of ReviewCannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible d...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
Publication date: Available online 18 June 2018 Source:Brain, Behavior, and Immunity Author(s): Silvia Tietz, Therese Périnat, Gretchen Greene, Gaby Enzmann, Urban Deutsch, Ralf Adams, Beat Imhof, Michel Aurrand-Lions, Britta Engelhardt In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) autoaggressive CD4+ T cells cross the blood-brain barrier (BBB) and cause neuroinflammation. Therapeutic targeting of CD4+T-cell trafficking into the CNS by blocking α4-integrins has proven beneficial for the treatment of MS but comes with associated risks, probably due to blocking ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: 1 October 2018 Source:NeuroImage, Volume 179 Author(s): Jaeyeon Yoon, Enhao Gong, Itthi Chatnuntawech, Berkin Bilgic, Jingu Lee, Woojin Jung, Jingyu Ko, Hosan Jung, Kawin Setsompop, Greg Zaharchuk, Eung Yeop Kim, John Pauly, Jongho Lee Deep neural networks have demonstrated promising potential for the field of medical image reconstruction, successfully generating high quality images for CT, PET and MRI. In this work, an MRI reconstruction algorithm, which is referred to as quantitative susceptibility mapping (QSM), has been developed using a deep neural network in order to perform dipole deconvolution, w...
Source: NeuroImage - Category: Neuroscience Source Type: research
AbstractMultiple sclerosis (MS) is a neurological disease of the central nervous system which can lead to a range of severe physical disabilities. A large proportion of those affected will experience cognitive impairment, which is associated with a worse prognosis. Effective assessment of cognition in MS has been problematic due to a lack of suitable scales. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) was developed in 2010 as part of an international endeavour to facilitate cognitive assessment.AimThe aim of this systematic review and meta-analysis was to synthesise the available literature...
Source: Neurology and Therapy - Category: Neurology Source Type: research
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