Relapsing Remitting Multiple Sclerosis and its Relationship with the Immune System and Oxidative Stress
Conclusion: Dietary intake of PUFAs and melatonin could also be considered as adjuvant treatments for that clinical course of relapsing-recurrent multiple sclerosis. Further studies focusing on the role of endocannabinoids derived from PUFA´s in MS are needed.
We examined overall correct classification of disability categories (i.e., mild, moderate, or severe disability) by the PDDS/BR in relation to the EDSS. Test-retest reproducibility of PDDS/BR scores was examined in a subsample of 31 participants after 15 days. Results: There was a strong relationship between the PDDS/BR and EDSS scores (ρ= 0.723, p
By collecting data on MS patients’ activities and abilities, parent company Roche Group hopes to create new drugs and diagnostics to combat this deadly disease Biotechnology company Genentech, a subsidiary of multinational pharmaceutical/diagnostics company Roche Holdings AG, has developed a smartphone application (app) that enables patients with Multiple Sclerosis (MS) to monitor and track their […]
Katja Vohl, Alexander Duscha, Barbara Gisevius, Johannes Kaisler, Ralf Gold, Aiden Haghikia
Tobias D. Faizy, Gabriel Broocks, Christian Thaler, Geraldine Rauch, Pimrapat Gebert, Klarissa H. St ürner, Fabian Flottmann, Hannes Leischner, Helge C. Kniep, Jan-Patrick Stellmann, Christoph Heesen, Jens Fiehler, Susanne Gellißen, Uta Hanning
ConclusionsAlthoughVT for [18F]GE-180 is low, indicating low brain penetration, half the signal shown by MS subjects reflected specific TSPO binding.VT for [11C]PBR28 was higher and two thirds of the binding was non-specific. No brain ROIs were devoid of specific signal, further confirming that true reference tissue approaches are potentially problematic for estimating TSPO levels.
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(Kessler Foundation) Dr. Dobryakova conducts clinical research in populations with cognitive dysfunction caused by traumatic brain injury and multiple sclerosis. She incorporates functional neuroimaging in her research, which focuses on the activity of the fronto-striatal network in fatigue and outcome processing in these populations. Her findings indicate that noninvasive, nonpharmacologic interventions may be useful for addressing deficits in learning processes, and in ameliorating the impact of debilitating cognitive fatigue.
Manca, A, Dvir, Z, and Deriu, F. Meta-analytic and scoping study on strength training in people with multiple sclerosis. J Strength Cond Res 33(3): 874–889, 2019—Aim of the study was to determine a pooled estimate of effect on muscle strength and functional capacity induced by strength training in people with multiple sclerosis (PwMS). Five databases and 2 public registries were searched from inception to May 2017. Indexing terms used were: “multiple sclerosis,” “resistance training,” and “strength training.” After title/abstract screening, 2 independent reviewers evaluated t...
In conclusion, there is much to explore with post-mortem MRI and histology studies, which can eventually be of high relevance for clinical pra ctice.