Single routine offer of a blood test for prostate cancer did not save lives

Expert commentary is provided for a study which found no difference in rates of prostate cancer death for screening vs no screening. Screening may increase diagnoses but does not reduce deaths. Trials like this one challenge “advances” that appear common sense but may do harm.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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In a recent study, men with inflammatory bowel disease had higher PSA levels and were four to five times more likely to develop prostate cancer than those in the control group, the investigators found.
Source: WebMD Health - Category: Consumer Health News Source Type: news
In this study cationic liposomes of cabazitaxel (CBX) and silibinin (SIL) were prepared with an aim to kill cancer cells and CSCs for prostate cancer. CBX act as cancer cell inhibitor and SIL as CSC inhibitor. Hyaluronic acid (HA), an endogenous anionic polysaccharide was coated on cationic liposomes for targeting CD44 receptors over expressed on CSCs. Liposomes were prepared by ethanol injection method with particle size below 100 nm and entrapment efficiency of more than 90% at 10% w/w drug loading. Liposomes were characterized by dynamic light scattering, transmission electron microscopy, 1H nuclear magnetic reso...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Condition:   Prostate Cancer Intervention:   Other: Standard care plus exercise Sponsors:   University of East Anglia;   Norfolk and Norwich University Hospitals NHS Foundation Trust Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
According to a new study, inflammatory bowel disease increases the risk of developing prostate cancer. This finding opens up a challenging clinical debate.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Crohn's / IBD Source Type: news
ConclusionsThe onset of a second primary tumour was related with the primary treatment given; thus the risk for those treated with radiotherapy and androgen deprivation therapy more than doubled.ResumenIntroducción y objetivosLa aparición de segundos tumores primarios en pacientes con cáncer de próstata de alto riesgo debe tenerse en cuenta en la evolución natural de la enfermedad. Nuestro objetivo es evaluar la influencia del tratamiento primario con intención curativa de dichos pacientes en el desarrollo de segundos tumores primarios.Material y métodosEstudio retrospectivo...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
Publication date: Available online 13 December 2018Source: Actas Urológicas Españolas (English Edition)Author(s): J.M. Cózar, B. Miñana, F. Gómez-Veiga, A. Rodríguez-Antolín, GESCAP GroupAbstractAimsTo describe the 3-year progression-free survival (PFS), overall survival (OS) and disease-specific mortality in the prospective prostate cancer GESCAP cohort, as well as the progression to castration resistance in patients on hormone therapy.Material and methodsProspective, observational, epidemiological, multicentre study. Of the 4087 patients recruited, 3843 were evaluable. The...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
ConclusionsThe diagnostic performance of CB in patients with at least one previous negative biopsy was 44%, increasing according to the PI-RADS grade, and low in PI-RADS 3. No clinical variable predictive of cancer was found in patients with PI-RADS 3.ResumenIntroducciónEvaluación de la efectividad de la biopsia cognitiva (BC) en los pacientes con sospecha clínica de cáncer de próstata (caP) y al menos una biopsia negativa (BTR).Material y métodoAnálisis retrospectivo de 144 pacientes con al menos una BTR y una resonancia magnética nuclear (RMN) previa. Los nód...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
This study compared magnetic resonance imaging-guided biopsy (MRI-GB) and transrectal ultrasound guided biopsy (TRUS-GB) with the final histology of the radical prostatectomy (RP) specimen.Methods: Our subjects were 229 patients with prostate cancer (PCa), proven histopathologically using MRI-GB or TRUS-GB, who underwent RP at our center between December 2015 and December 2016. The main group included 92 patients who underwent MRI-GB and the control group included 137 patients who underwent 12-core TRUS-GB. Histological findings for RP specimens were compared with those from biopsies. We also evaluated predictors of upgrad...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
To explore the role of phospholipase D1 (PLD1) mRNA in transition of prostate cancer (PCa) cells to androgen independence, we used Arraystar Human LncRNA Microarray V3.0 to detect and compare the differential expression of PLD1 and its signaling pathway-related gene in standard androgen dependence prostate cancer (ADPC) cell line LNCaP before and after the occurrence of androgen independence prostate cancer (AIPC) transition. In addition, we used the shRNA lentiviral vector to inhibit the PLD1 mRNA expression and observed its effect on LNCaP cell proliferation after AIPC transition by using MTS method. The results showed t...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Background: Several reports have revealed the presence of lymph nodes in the prostatic anterior fat pad (PAFP). To date, no study has described the characteristics of Taiwanese patients harboring PAFP lymph nodes with metastatic prostate cancer involvement.Method: Between December 2006 and May 2015, a total of 849 consecutive patients underwent robot-assisted laparoscopic radical prostatectomy with PAFP dissection. Pathological examination of the dissected PAFP was conducted to assess the presence of lymphoid tissue and prostate cancer involvement.Results: Of the 849 patients, 76 (9.0%) had 1-3 PAFP lymph nodes. Moreover, ...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
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