Single routine offer of a blood test for prostate cancer did not save lives

Expert commentary is provided for a study which found no difference in rates of prostate cancer death for screening vs no screening. Screening may increase diagnoses but does not reduce deaths. Trials like this one challenge “advances” that appear common sense but may do harm.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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AbstractObjectiveTo evaluate factors associated with use of patient navigation in a prostate cancer population and identify whether navigation is associated with prolonged  time to care. Cancer patient navigation has been shown to improve access to cancer screening, diagnosis, and treatment, but little is known about patient navigation in prostate cancer care.MethodsAll men diagnosed with localized prostate cancer between 2009 and 2015 were abstracted from the MaineHealth  multi-specialty tumor registry. Regression analyses controlling for patient-, disease-, and system-level factors evaluated characteristics ass...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionIn conclusion, this study illustrates that the application and benefits of HS on reducing GI rectal dose endpoints and toxicities during prostate cancer RT can be reliably replicated in a community setting similar to centres participating in the randomised trial under high quality assurance trial monitoring.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionThere is a need to enhance a constant patient –HCP dialogue, and both groups need to make a conscious effort in that direction. This would help in increasing patients’ awareness of risks, having better treatment choice and acceptance, and reducing side-effects.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
In this study, a sensitive electrochemical aptasensor for detecting PSA based on coral-like poly-aniline (PANI)/gold nano-particles (AuNPs) and the peptides was constructed. Coral-like PANI and AuNPs with the diameter of 50-80 nm, as the substrate materials, were directly deposited on glass carbon electrode (GCE) by electrodeposited method. Then, the peptides, as the antifouling materials, were anchored on the modified-electrode, which not only can form antifouling surface to reduce nonspecific adsorption, but also can be as a medium between the modified-electrode and PSA aptamer. Finally, the PSA aptamer was immobi...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
WEDNESDAY, May 22, 2019 -- " Watchful waiting " is on the rise overall among U.S. men with low-risk prostate cancer, but black men remain less likely to opt for it, a new study finds. For the study, researchers examined 2010-2015 data on more than...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Publication date: Available online 20 May 2019Source: Respiratory Medicine Case ReportsAuthor(s): Yukihisa Hatakeyama, Sho Yoshimura, Taira Ninomaru, Shodai Fujimoto, Rei Takamiya, Kayoko Okamura, Nobuya Sano, Hisashi OhnishiAbstractA 78-year-old Japanese man who had undergone total prostatectomy for prostate cancer (pT3cN1M0, Gleason score 3 + 3) 20 years previously was referred to the Respiratory Medicine Department of our institution because of a 1-week history of chest pain and cough. Computed tomography showed multiple small nodules and mediastinal lymph node enlargement. Bronchoscopy revealed multiple soft ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Condition:   Prostate Cancer Intervention:   Device: mpMRI Sponsor:   Institut Paoli-Calmettes Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 21 May 2019Source: Molecular and Cellular EndocrinologyAuthor(s): John J. Flanagan, Taavi K. NeklesaAbstractNuclear receptors comprise a class of intracellular transcription factors whose major role is to act as sensors of various stimuli and to convert the external signal into a transcriptional output. Nuclear receptors (NRs) achieve this by possessing a ligand binding domain, which can bind cell permeable agonists, a DNA-binding domain, which binds the upstream sequences of target genes, and a regulatory domain that recruits the transcriptional machinery. The ligand binding alters the a...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
(Dana-Farber Cancer Institute) At a time when a growing number of men with prostate cancer considered 'low risk' are opting for active surveillance or watchful waiting rather than immediate treatment with surgery or radiation, a new study reveals that black men are less likely than white men to adopt an active surveillance strategy for their disease.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Authors: Elkady AI Abstract Prostate cancer is still at the forefront causes of cancer-related morbidity and mortality in men throughout the globe. The disease is initiated and fostered by a subset of cancer stem cells (CSCs). Costus speciosus is an oriental herb used in traditional medicine and is a source of bioactive compounds with known pharmacological activities. The present study aims to evaluate the anticancer property of varied extracts isolated from C. speciosus against the human prostate cancer PC-3 cells. Extracts derived from C. speciosus were analyzed by chromatography-mass spectrometry and their effec...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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