Hospital superbugs could be destroyed with sheeting inspired by shark skin

Scientists have designed a coating material infused with antimicrobials based on the patterned diamond-like texture of sharks's skin that allows bacteria to simply wash off as they swim.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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SCIENTISTS are developing a DNA test to identify infections within hours and beat deadly hospital “superbugs”. Experts believe the government-funded research will help save lives as well as prevent the prescribing of unnecessary antibiotics, which is fuelling drug-resistant diseases.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Atia R, Jouve L, Knoeri J, Georgeon C, Laroche L, Borderie V, Bouheraoua N Abstract Infectious keratitis are a frequent cause of ocular morbidity. Today, new treatments are necessary to combat the emergence of antibiotic resistant germs. Corneal collagen cross-linking has been suggested to treat corneal infectious (PACK-CXL). Its action would be both antimicrobial and protective for the cornea, increasing its biochemical resistence to proteolytic enzymes. In vivo, PACK-CXL might demonstrate good efficacy against bacterial keratitis, contrary to herpetic keratitis for which it is contraindicated. For fungal...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
In this study, the effects of two types of cross-linking agents, sodium sulfate vs. tripolyphosphate, along with molecular weight (Mw) of chitosan, low vs. high Mw, and different sonication treatments, time and power, were assessed to determine the optimal conditions to enhance antimicrobial activity against bacterial pathogens. Physiochemical characteristics of the engineered chitosan nanoparticles were determined. It was observed that 20 min sonication time, low Mw of chitosan, Sodium sulfate as cross-linker, and particle size smaller than <300 nm, showed the greatest antimicrobial activity. Chitosan nanoparticles...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
(Purdue University) Purdue University researchers have identified a new compound that in preliminary testing has shown itself to be as effective as antibiotics approved by the FDA to treat life-threatening infections while also appearing to be less susceptible to bacterial resistance.The compound has been potent against antibiotic-resistant pathogens such as MRSA, which is often found in hospitals and other health care settings, and vancomycin-resistant Staphylococcus, with vancomycin long considered a drug of last resort.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
We report the good fit of the SR E.coli to known kinetic models (>96% R2), and analytically present the necessary treatment timed for total inactivation and halting their post-treatment regrowth capability. For all treatment methods, the AR was found to decrease during treatment, prior to loss of cultivability (5–15% lower time for 4-log inactivation). UVB irradiation was determined as the key factor of loss of cultivability, AR and regrowth. Solar/H2O2 and photo-Fenton presented fast inactivation rates, ensured no regrowth of ARB, and indicated moderate effect on modifying the SR of E. coli, with similar inactiva...
Source: Catalysis Today - Category: Chemistry Source Type: research
Background: Electronic health records provide the opportunity to assess system-wide quality measures. Veterans Affairs Pharmacy Benefits Management Center for Medication Safety uses medication use evaluation (MUE) through manual review of the electronic health records. Objective: To compare an electronic MUE approach versus human/manual review for extraction of antibiotic use (choice and duration) and severity metrics. Research Design: Retrospective. Subjects: Hospitalizations for uncomplicated pneumonia occurring during 2013 at 30 Veterans Affairs facilities. Measures: We compared summary statistics, individ...
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
Clinically, MRSA VAP is rare. However, MRSA is a common colonizer of respiratory secretions in ventilated adults in ICUs. The classic clinical features of bona fide S. aureus pneumonia are well known from experience with S. aureus pneumonia with influenza. In a pVAP ICU patient, without the clinical findings of S. aureus pneumonia, i.e., otherwise unexplained new high fevers/chills, hemorrhagic tracheobronchitis, elastin fibers in bronchial secretions, hypotension, rapidly cavitation, and thick walled cavities in one/both lungs [1,2].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Letter to the Editor Source Type: research
The objective of this study was to characterize antibiotic therapy for NH residents  and compare appropriateness based on setting of prescription initiation.MethodsThis was a retrospective, cross-sectional multi-center study that occurred in five NHs in southern Wisconsin between January 2013 and September 2014. All NH residents with an antibiotic prescribing events for suspected lower respiratory tract infections (LRTI), skin and soft tissue infections (SSTI), and urinary tract infections (UTI), initiated in-facility, from an emergency department (ED), or an  outpatient clinic were included in this sample. We as...
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
The new research of 316 volunteers, by Finnish researchers at Helsinki University, is the latest in a long-line of scientific trials to try and discover what else is fueling untreatable superbugs.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusion: The predominance of ST-239 in this region during the last eight years is a major concern. It also has a disturbing impact on the management of staphylococcal infections. Moreover, the SCCmec type IV strain is able to disseminate rapidly in hospital environments, demanding an improvement in infection-control policy. PMID: 29887890 [PubMed]
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
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