Hospital superbugs could be destroyed with sheeting inspired by shark skin

Scientists have designed a coating material infused with antimicrobials based on the patterned diamond-like texture of sharks's skin that allows bacteria to simply wash off as they swim.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in individuals with cystic fibrosis (CF) has increased significantly. While studies demonstrate that persistent MRSA infection in CF is associated with poor clinical outcomes, there are no randomized controlled studies informing management.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Publication date: Available online 15 August 2018Source: Microbial PathogenesisAuthor(s): Niranjana Sri Sundarmoorthy, Karthik Mithra, Jayasankari Senthil Ganesh, Himesh Makala, Robert Lotha, Shamprasad R. Bhanuvalli, Venkatasubramanian Ulaganathan, Vaidehi Thirunaukarasu, Aravind Sivasubramanian, Saisubramanian NagarajanAbstractA series of ferulic acid (FA) derivatives were synthesized and evaluated for its ability to inhibit NorA efflux in methicillin resistant Staphylococcus aureus (MRSA), by in silico docking analysis. Based on prediction from glide scores and ability to reduce EtBr MIC, two of the ten derivatives S3- ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In this study, we aimed to investigate biofilm formation characteristics in clinical Staphylococcus aureus (S. aureus) isolates with erythromycin (ERY) resistance from China and further analyze their correlations with antimicrobial susceptibility and molecular characteristics.Methodology A total of 276 clinical isolates of ERY-resistant S. aureus, including 142 methicillin-resistant S. aureus (MRSA) strains and 134 methicillin-susceptible S. aureus (MSSA) strains, were retrospectively collected in China. Biofilms were determined by crystal violet staining and ERY resistance genes (ermA, ermB and ermC) were detected by poly...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 14 August 2018Source: Microbial PathogenesisAuthor(s): Praveen Rishi, Shania Vij, Indresh Kumar Maurya, Ujjwal Jit Kaur, Sanjay Bharati, Rupinder TewariAbstractFast emerging antibiotic resistance in pathogens requires special attention for strengthening the reservoir of antimicrobial compounds. In view of this, several peptides with known antimicrobial activities have been reported to enhance the efficacy of antibiotics against multidrug resistant (MDR) pathogens. In the present study, potential of peptides having distinct mechanism of action, if any, was evaluated to improve the efficacy...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 17 August 2018Source: International Journal of PharmaceuticsAuthor(s): Danford Mhule, Rahul S. Kalhapure, Mahantesh Jadhav, Calvin A. Omolo, Sanjeev Rambharose, Chunderika Mocktar, Sanil Singh, Ayman Y. Waddad, Valence M.K Ndesendo, Thirumala GovenderAbstractStimuli-responsive nano-drug delivery systems can optimize antibiotic delivery to infection sites. Identifying novel lipids for pH responsive delivery to acidic conditions of infection sites will enhance the performance of nano-drug delivery systems. The aim of the present investigation was to synthesize and characterize a biosafe nov...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
This invention, offered for licensing and commercial development, relates to a new class of naturally occurring antimicrobial compounds called Chrysophaetins, and to their synthetic analogues. Isolated from an alga species, the mechanism of action of these compounds is through the inhibition of bacterial cytoskeletal protein FtsZ, an enzyme necessary for the replication of bacteria. FtsZ is responsible for Z-ring assembly in bacteria, which leads to bacterial cell division. Highly conserved among all bacteria, FtsZ is a very attractive antimicrobial target.The chrysophaetin exhibits antimicrobial activity against drug resi...
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research
Conclusions Despite increased awareness of CA-MRSA, more educational efforts focusing on best practices and education are needed, especially with athletes and the medical community involved in their care.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: Epidemiology Source Type: research
Publication date: Available online 16 August 2018Source: Microbial PathogenesisAuthor(s): Walid A. Lotfy, Sahar W. Mostafa, Amr A. Adel, Khaled M. GhanemAbstractThe emergence of extensive antibiotics resistant bacteria increased the demands for finding out new sources of antimicrobial agents. Marine niches were reported to be rich in many competent producers of significant bioactive compounds. On the course of screening program for new antimicrobials, a Bacillus strain was isolated from Alexandria sea shores, Egypt. According to the morphological, cultural and biochemical characteristics, 16S rRNA sequence analysis and mat...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
This study focused on the utilisation of Streptomyces isolate S12 purified from waste discharge soil in the biological synthesis of silver (Ag), selenium (Se), and zinc oxide (ZnO) NPs. The isolate S12 was related to Streptomyces enissocaesilis according to 16S rRNA sequence analysis, morphological characteristics, and biochemical reactions. The cell-free supernatant has been used for the synthesis of Ag, Se, and ZnO NPs. The synthesised NPs were characterised using ultraviolet–visible spectroscopy, dynamic light scattering (DLS), transmission electron microscopy, and Fourier transform infrared spectroscopy. The biog...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Publication date: Available online 16 August 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): M. Bertuola, A. Miñán, C.A. Grillo, M.C. Cortizo, M.A. Fernández Lorenzo de MeleAbstractThe prevention of microbial biofilm formation on a biomaterial surface is crucial in avoiding implants failures and the development of antibiotic resistant bacteria. It was reported that biodegradable Mg alloys may show antimicrobial effects due to the alkalinization of the corroding area. However, this issue is controversial and deserves a detailed study, since the processes occurring at the [biodegradable meta...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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