Neural Responsiveness to Reward as an Index of Depressive Symptom Change Following Cognitive-Behavioral Therapy and SSRI Treatment.

Neural Responsiveness to Reward as an Index of Depressive Symptom Change Following Cognitive-Behavioral Therapy and SSRI Treatment. J Clin Psychiatry. 2018 Jun 12;79(4): Authors: Burkhouse KL, Gorka SM, Klumpp H, Kennedy AE, Karich S, Francis J, Ajilore O, Craske MG, Langenecker SA, Shankman SA, Hajcak G, Phan KL Abstract OBJECTIVE: Reward positivity (RewP), a neurophysiologic index of reward responsivity, is consistently reduced in participants with depression and, to a lesser extent, anxiety. It remains unknown, however, whether RewP can be altered as psychiatric symptoms change with treatment. The current study addressed this question by examining differences in RewP within patients before and after 12 weeks of treatment with a selective serotonin reuptake inhibitor (SSRI) or cognitive-behavioral therapy (CBT). We also examined the utility of RewP as a predictor of symptom change during CBT and SSRI treatment. METHODS: Participants were recruited between 2014 and 2017 and included adults with a primary DSM-5 anxiety or depressive disorder (n = 63) and healthy controls (n = 25). At baseline and 12 weeks, participants completed a monetary award task while electroencephalogram (EEG) was recorded. Between EEG sessions, patients completed CBT or SSRI treatment. RESULTS: At baseline, higher levels of depressive symptoms were associated with a more attenuated RewP. We found no significant differences between patients and healthy controls in the degree...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

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Conclusion: The results point to the long-term effectiveness of CBT under routine conditions for a wide array of problems, especially when compared to the long-term effects of medical treatment. It is noteworthy that the results at follow-up were even better than at posttreatment, indicating further improvement. However, about a quarter of the patients did not respond sufficiently to therapy, neither concerning short-term nor long-term effects.Psychother Psychosom
Source: Psychotherapy and Psychosomatics - Category: Psychiatry & Psychology Source Type: research
Authors: Konstantakopoulos G Abstract There is now general agreement that lack of insight is not merely a fundamental aspect of delusions and hallucinations, or just a symptom of psychotic disorders but rather a multi-dimensional construct. Several different components of insight have been proposed and empirically examined during the last three decades, such as the ability to recognize that one has a mental illness, the capacity to relabel unusual mental events as pathological, the specific attribution of one's symptoms to having a mental illness, awareness of illness' consequences, and compliance with treatment.1 ...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
Conditions:   Depression;   Anxiety;   PTSD;   Suicidal Ideation;   Substance Use Disorders;   Unsafe Sex;   Coping Behavior Intervention:   Behavioral: AWARE intervention Sponsors:   Boston University Charles River Campus;   Harvard University Completed
Source: - Category: Research Source Type: clinical trials
Conditions:   Anxiety;   Depression;   Posttraumatic Stress Disorder;   Psychological Distress Intervention:   Behavioral: Problem Management Plus (PM+) Sponsors:   Istanbul Sehir University;   European Commission Enrolling by invitation
Source: - Category: Research Source Type: clinical trials
Publication date: August 2019Source: Journal of Psychiatric Research, Volume 115Author(s): Alan Shafer, Federico DazziAbstractA meta-analysis of the results of 45 factor analyses (n = 22,812) of the Positive and Negative Syndrome Scale (PANSS) was conducted. Meta-analyses of the PANSS was conducted using both a co-occurrence similarity matrix and reproduced correlations. Both methods produced similar results. Five factors (Positive Symptoms, Negative Symptoms, Disorganization, Affect and Resistance) emerged clearly across both analyses. The factors and the items defining them were Positive Symptoms (P1 Delusions, G9 Un...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
 Being hospitalized for any reason is never a fun time, but there are some instances where it can be a harrowing experience. This is especially true for psychiatric patients, who are already in a crisis even before being plunged into the hospital atmosphere, which can overwhelm them. This disconnect between patients and hospital staff has long been an issue. Today’s guest shares some insights on her work to improve this relationship.   Subscribe to Our Show! And Remember to Review Us! About Our Guest John M. Grohol, Psy.D. is the founder &CEO of, a mental health an...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Research The Psych Central Show Dr John Grohol Gabe Howard Internet Vincent M. Wales Source Type: blogs
ConclusionsThe findings, although preliminary, provide additional evidence for the utilization of tCBT in the effective treatment of emotional disorders. Further research into the implementation of the tCBT for emotional disorders protocol through a randomized controlled trial involving groups of participants with a range of emotional disorder diagnoses is warranted.
Source: Journal of Behavior Therapy and Experimental Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 21 May 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Angela Jacques, Nicholas Chaaya, Kate Beecher, Syed Aoun Ali, Arnauld Belmer, Selena BartlettAbstractIn 2016 the World Health Organization reported 39% of the world’s adult population (over 18 y) was overweight, with western countries such as Australia and the United States of America at 64.5% and 67.9% respectively. Overconsumption of high fat/sugar containing food and beverages contribute to the development of obesity. Neural plasticity that occurs as a result of long term sugar consumption has been shown to redu...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Publication date: Available online 22 May 2019Source: NeuroscienceAuthor(s): Qian Li, Shenbin Liu, Xiaocang Zhu, Wenli Mi, Qiliang Maoying, Jun Wang, Jin Yu, Yanqing WangAbstractThe chronic neuropathic pain-associated psychiatric disorders have seriously disturbed the quality of patients' life, such as depression and anxiety. Neuroinflammation in the hippocampus plays an important role in the neuropathic pain-associated depressive and anxiety disorders, but the underlying mechanism has not been thoroughly elucidated to date. The Nod-like receptor protein (NLRP)-1 inflammasome, which controls the production of pro-inflammat...
Source: Neuroscience - Category: Neuroscience Source Type: research
In Reply First of all, we would like to thank Dr Ghadami for his interest and comments on our research. And also, we agree with his opinion that sleep problems may contribute to the development of depression and anxiety in patients with chronic rhinosinusitis (CRS). Importantly, as we emphasized in our research, we found that patients with CRS without nasal polyp showed a higher risk of developing depression and anxiety than those with CRS with nasal polyps. However, we could not compare the degree of sleep impairment between patients in the 2 groups because the database used does not provide information from sleep-related...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
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