Prostate cancer symptoms: Spotting this in your urine could be warning sign of the disease

PROSTATE cancer symptoms don ’t tend to sow until the cancer has grown large enough to put pressure on the urethra. Many men diagnosed with this cancer won’t shown signs at all. While it’s rare, if you spot this in your urine it could ring alarm bells for the disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Authors: Ye J, Chu C, Chen M, Shi Z, Gan S, Qu F, Pan X, Yang Q, Tian Y, Wang L, Yang W, Cui X Abstract Prostate cancer (PCa) is one of the most commonly diagnosed malignancies, and 90% of advanced prostate cancer patients relapse after therapy. Trophinin associated protein (TROAP) is essential for centrosome integrity and proper bipolar organisation of spindle assembly during mitosis and plays an essential role in proliferation. We found that TROAP expression correlates with patient survival and speculated that it may be involved in PCa progression. The Oncomine database tool (http://www.oncomine.org) was used to ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Publication date: Available online 15 November 2018Source: Journal of Molecular StructureAuthor(s): Khatoon Seraj, Mohammad Asadollahi-BaboliAbstractThe lysine specific demethylase 1 (LSD1) overexpression is linked to a lung, breast and prostate cancers. In order to explore significant biochemical features affecting LSD1 inhibition mechanism and help design new potent inhibitors, molecular docking, classification and quantitative structure-activity relationship (QSAR) were performed based on 5-hydroxypyrazole analogs. The molecular docking studies indicate residues of Arg316, Thr810 and Tyr761 with total binding energy mor...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 15 November 2018Source: European UrologyAuthor(s): Kathia De Man, Piet Ost
Source: European Urology - Category: Urology & Nephrology Source Type: research
Conditions:   Prostate Cancer;   Quality of Life;   Orchiectomy Interventions:   Procedure: Bilateral simple orchidectomy (BSO);   Procedure: Bilateral Subcapsular Orchidectomy;   Procedure: Bilateral Epididymal-sparing Orchidectomy Sponsor:   University College Hospital, Ibadan Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The next-generation antiandrogen has received a positive opinion for nonmetatatic castration-resistant prostate cancer (CRPC), considered to be an unmet medical need.International Approvals
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news
The next-generation antiandrogen has received a positive opinion for nonmetatatic castration-resistant prostate cancer (CRPC), considered to be an unmet medical need.International Approvals
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
Publication date: Available online 16 November 2018Source: Stem Cell ResearchAuthor(s): Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Daniela Kurfűrstová, Radek Vrtěl, Vladimír Študent, Lucie Jurečková, Volodymyr Porokh, Aleš Hampl, Karel SoučekAbstractA human induced pluripotent stem cell line was generated from cancer-associated fibroblasts of a 68-years old patient with diagnosed prostate adenocarcinoma (PCa). The fibroblast cell line was reprogrammed with Epi5™ Episomal iPSC Reprogramming Ki...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b14940
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
Androgens such as testosterone and dihydrotestosterone are a critical driver of prostate cancer progression. Cancer resistance to androgen deprivation therapies ensues when tumors engage metabolic processes that produce sustained androgen levels in the tissue. However, the molecular mechanisms involved in this resistance process are unclear, and functional imaging modalities that predict impending resistance are lacking. Here, using the human LNCaP and C4-2 cell line models of prostate cancer, we show that castration treatment–sensitive prostate cancer cells that normally have an intact glucuronidation pathway that r...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Metabolism Source Type: research
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