Hay fever boom hits 20 million
MORE than 20 million Britons face hay fever hell after research identified a boom in pollen generated by grass. Health and weather experts have warned that victims will suffer heightened symptoms including running eyes, sneezing and respiratory problems.
CONCLUSION: The results of the study indicate that there could be a relationship between the expression of CCL-18 in nasal turbinate mucosa and the severity of allergic rhinitis. PMID: 30102123 [PubMed - as supplied by publisher]
Conditions: Asthma; Allergic Rhinitis; Allergic Conjunctivitis Interventions: Other: Active air purifier in respiratory allergies/asthma; Other: Sham air purifier Sponsor: Molekule Recruiting
ConclusionRMFE may have therapeutic potential for treating AR by modulating the relationships between Th1/Th2 responses.Graphical abstract
Publication date: Available online 10 August 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Yoshimasa Imoto, Tetsuji Takabayashi, Masafumi Sakashita, Takahiro Tokunaga, Taiyo Morikawa, Takahiro Ninomiya, Masayuki Okamoto, Norihiko Narita, Shigeharu Fujieda
This study observed commercial and Medicare Advantage with Part D health plan enrollees. Included subjects had claims with AR diagnostic codes during 01/01/11-12/31/15 and ≥1 SCIT claim during 01/01/13-12/31/15 (index date = first SCIT claim date). A control sample was chosen randomly at a 1:3 ratio of SCIT to controls. Inconsistent use was defined as a ≥90-day gap after ≥1 SCIT. Patient characteristics were compared between SCIT patients and controls. Costs were calculated for all SCIT patients and the inconsistent subgroup. RESULTS: Compared with controls (n = 394,479), SCIT (n= 1...
Authors: Kim DH, Han K, Kim SW Abstract PURPOSE: Our aim was to explore whether antibiotic exposure in children and adolescents is associated with the later development of allergic diseases, using nationwide population-based claims data. METHODS: We collected information from the National Health Insurance Service (2006-2015) database. A total of 5,626,328 children and adolescents were eligible for the study. We explored whether exposure to antibiotics over the prior 7 years affects the later development of allergic diseases. We ran 3 analytical models after adjusting for confounding factors including age, sex, ...
We developed a novel JC pollinosis mouse model, which was used to evaluate the efficacy, including the long-lasting effects, of SLIT. Our study emphasizes that SLIT modifies disease activity in a dose- and duration-dependent manner.
Conclusions: In view of the redundancy of cytokines and "united airway" theory, we propose a new concept that IL-25/IL-33/TSLP-fibrocyte axis may play a vital role in the abnormal epithelial-mesenchymal crosstalk in some endotypes of AADs. This novel idea will guide potential new intervention schema for the common treatment of AADs sharing common pathogenesis in the future. PMID: 30082531 [PubMed - in process]
Adenosine activates Gαs proteins and inhibits C3a-induced activation of human mast cells. Biochem Pharmacol. 2018 Aug 09;: Authors: Arizmendi N, Kulka M Abstract Anaphylatoxin C3a and adenosine receptors (AR) are implicated in the inflammatory process associated with allergic rhinitis and asthma by modifying mast cell (MC) responses. Possible interactions between these G-protein coupled receptor (GPCR) pathways in MCs has not yet been demonstrated. LAD2 human MC were stimulated with C3a in the presence or absence of AR agonists and antagonists and their adhesion, chemotaxis and mediator release ...