Higher CD45RA+ Regulatory T Cells in The Graft Improves Outcome in Younger Patients Undergoing T Cell Replete Haploidentical Transplantation: Where Donor Age Matters

Early and aggressive alloreactivity remains one of the major causes of morbidity and mortality following HLA-mismatched allogeneic hematopoietic stem cell transplantation (HSCT). Haploidentical family donor HSCT is emerging as the front-runner for alternate donor transplantation since the introduction of post-transplantation cyclophosphamide (PTCy) [1]. Based on the encouraging results witnessed in adults, we had extended PTCy based haploidentical HSCT to the pediatric age group. We had reported a high incidence of both acute graft-versus host disease (GVHD) [2] and post-transplantation hemophagocytic syndrome (PTHPS) without an infectious trigger [3], occurring within 35 days of HSCT in younger children undergoing PTCy-based haploidentical BMT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Original Article Source Type: research