Endothelial PPAR{gamma} (Peroxisome Proliferator-Activated Receptor-{gamma}) Is Essential for Preventing Endothelial Dysfunction With AgingNovelty and Significance [Oxidative Stress]

Little is known about mechanisms that control vascular aging, particularly at the cell-specific level. PPARγ (peroxisome proliferator–activated receptor-γ) exerts protective effects in the vasculature when activated pharmacologically. To gain insight into the cell-specific impact of PPARγ, we examined the hypothesis that genetic interference with endothelial PPARγ would augment age-induced vascular dysfunction. We studied carotid arteries from adult (11.6±0.3 months) and old (24.7±0.6 months) mice with endothelial-specific expression of a human dominant negative mutation in PPARγ driven by the vascular cadherin promoter (E-V290M), along with age-matched, nontransgenic littermates. Acetylcholine (an endothelium-dependent agonist) produced similar relaxation in arteries from adult nontransgenic and E-V290M mice and old nontransgenic mice. In contrast, responses to acetylcholine were reduced by>50% in old male and female E-V290M mice (P
Source: Hypertension - Category: Cardiology Authors: Tags: Vascular Biology, Vascular Disease Original Articles Source Type: research