A Better Flu Shot May Be On the Horizon. Here ’s Why

Each year, influenza viruses bring aches, pains, fever and overall misery to millions of people. The flu also leads to hundreds of thousands of hospitalizations and thousands of deaths. In a new paper published in Genome Medicine, researchers say a blood test may be able to identify which people are more likely to fight off the flu and which may have a harder time. And information from that same test could lead to new treatments — including more effective vaccines — that might make more people more flu-resistant. For four years, Purvesh Khatri, an associate professor of medicine and biomedical data science at Stanford University, and his colleagues have been parsing the immune system for clues about how best to ward off the flu virus. When they scanned the entire human genome for the genes that might be protective, they came up empty. So they decided to focus on the cells that made the most sense in their search — the immune cells whose job is to fight incoming microbes like influenza. They recruited 52 people who had their immune systems analyzed and then volunteered to inhale flu viruses to see if they became infected. The researchers learned that the people who experienced the worst flu symptoms had lower levels of certain kinds of immune cells known as natural killer cells, while those who didn’t get as sick seemed to have higher levels of these cells. MORE: A Record-Breaking Number of Kids Died During This Year’s Flu Season Khatri and his t...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime public health Source Type: news

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This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition. In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harveste...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Up until the first half of the twentieth century, large-scale health disasters were mostly due to natural causes (earthquakes, volcanoes, hurricanes, etc.) or infections (e.g., smallpox, influenza epidemics, cholera). But something peculiar happened as we entered the second half of the century: Health disasters due to natural causes became dwarfed by large-scale health disasters that are man-made. Here’s a list of the Six Worst U.S. Health Disasters of the Last 50 Years, mostly man-made phenomena that have exacted huge tolls: widespread disease, premature death, poorly managed (though nonetheless highly profitable fo...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle autoimmune gluten grain-free grains Inflammation low-carb Weight Loss Source Type: blogs
AbstractVaccines have been valuable tools in the prevention of infectious diseases, and the rapid development of new vectors against constantly mutating foreign antigens in viruses such as influenza has become a regular, seasonal exercise. Harnessing the immune response against self-antigens is not necessarily analogous or as achievable by iterative processes, and since the desired outcome includes leaving the targeted organism intact, requires some precision engineering. In vaccine-based treatment of autoimmunity and cancer, the proper selection of antigens and generation of the desired antigen-specific therapeutic immuni...
Source: Seminars in Immunopathology - Category: Pathology Source Type: research
Conclusions Safe, effective, affordable homeopathic immunizations exist for almost every illness now targeted by unsafe, costly, failed conventional vaccinations. If the goal were to provide protection from disease in a safe manner, why aren’t these safe, inexpensive homeopathic options made available to the public on a large scale? Millions of dollars in healthcare costs would be saved by using a less expensive immunization. Most significant would be the reduction of vaccine-caused diseases including autism, asthma, allergies, autoimmune disorders, diabetes, and cancer. The health of Americans would improve in drama...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Recent Articles Top Stories homeopathic vaccination homeopathic vaccines truth about vaccines Source Type: blogs
Conclusion The vaccination comprises a misguided and unsafe national health care program which claims to prevent disease. Many significant health injuries are associated with vaccinating adults. Government resources are being spent researching and developing new and different vaccinations. Subjecting adults to more vaccinations is likely to cause more health injury and illness. References: http://www.vaccinationcouncil.org/2012/07/05/herd-immunity… http://www.cdc.gov/chronicdisease/overview/ http://www.vaccinationcouncil.org/2011/02/18/60-lab-studies… http://www.cdc.gov/vaccines/schedules/hcp/adult.html...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Recent Articles Top Stories adult vaccination adult vaccines new vaccines shingles vaccine truth about vaccines Source Type: blogs
Contact: Sarah Avery Phone: 919-660-1306 Email:sarah.avery@duke.eduhttps://www.dukehealth.orgFOR IMMEDIATE RELEASE on Wednesday, Aug. 17, 2016DURHAM, N.C. – Molecules that scavenge debris from dying cells appear to halt the cycle of chronic inflammation in lupus, while also enhancing the body’s ability to combat flu, according to Duke Health studies in mice.The molecules, called polymers, have commonly been used in gene-transfer experiments because they bind to the nucleic acid in DNA and RNA. When deployed directly in mice with lupus or an acute flu infection, the polymers home in on the DNA and RNA refuse fro...
Source: DukeHealth.org: Duke Health Features - Category: Pediatrics Tags: Duke Medicine Source Type: news
Autoimmune diseases are caused by a range of malfunctions in the configuration of the immune system that lead it to attack the patient's own tissues, causing chronic inflammation at the least and eventually fatal damage at the worst. Most incidence of autoimmune disease is not very age-related, but aging does bring a rising level of autoimmunity as the immune system becomes increasingly dysfunctional and ineffective, falling into the state known as immunosenescence. One contributing cause of immune aging is a limited and diminishing supply of new immune cells, and one potential approach to treatment is to restore the thymu...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
In the paper quoted below, researchers review the links between immune system dysfunction in aging and pulmonary diseases - diseases of the lungs, ranging from infections to fibrosis. This is just one of many classes of medical condition that are much more serious and frequent in the elderly. We all know that the immune system fails in its duties with aging. The elderly are frail in large part because they have little resistance to infection, their healing is impaired, and other functions depending on components of the immune system are similarly diminished. This is partially the result of high levels of various forms of ...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Abstract Multiple sclerosis (MS) progression to mortality may not be solely determined by the underlying autoimmune process. We conducted a study in a large cohort of MS patients with the aim of describing characteristics of MS patients and identification of predictors for all-cause mortality in this patient group. We performed a retrospective analysis of primary care data from the UK Clinical Practice Research Datalink. Incident MS cases diagnosed between 1993 and 2006 were identified and validated using electronic and original medical records. Patients were followed to identify deaths; hazard ratios (HRs) and 95...
Source: Journal of Neurology - Category: Neurology Source Type: research
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