A Better Flu Shot May Be On the Horizon. Here ’s Why

Each year, influenza viruses bring aches, pains, fever and overall misery to millions of people. The flu also leads to hundreds of thousands of hospitalizations and thousands of deaths. In a new paper published in Genome Medicine, researchers say a blood test may be able to identify which people are more likely to fight off the flu and which may have a harder time. And information from that same test could lead to new treatments — including more effective vaccines — that might make more people more flu-resistant. For four years, Purvesh Khatri, an associate professor of medicine and biomedical data science at Stanford University, and his colleagues have been parsing the immune system for clues about how best to ward off the flu virus. When they scanned the entire human genome for the genes that might be protective, they came up empty. So they decided to focus on the cells that made the most sense in their search — the immune cells whose job is to fight incoming microbes like influenza. They recruited 52 people who had their immune systems analyzed and then volunteered to inhale flu viruses to see if they became infected. The researchers learned that the people who experienced the worst flu symptoms had lower levels of certain kinds of immune cells known as natural killer cells, while those who didn’t get as sick seemed to have higher levels of these cells. MORE: A Record-Breaking Number of Kids Died During This Year’s Flu Season Khatri and his t...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime public health Source Type: news

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Ectopic lymphoid structures form in a wide range of inflammatory conditions, including infection, autoimmune disease, and cancer. In the context of infection, this response can be beneficial for the host: influenza A virus infection–induced pulmonary ectopic germinal centers give rise to more broadly cross-reactive antibody responses, thereby generating cross-strain protection. However, despite the ubiquity of ectopic lymphoid structures and their role in both health and disease, little is known about the mechanisms by which inflammation is able to convert a peripheral tissue into one that resembles a secondary lymph...
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Infectious Disease and Host Defense, Mucosal Immunology Articles Source Type: research
The T-cell receptor (TCR) repertoire in patients with chronic lymphocytic leukemia (CLL) is more clonal than in healthy individuals. Shared TCR clonotypes among patients may reflect the expansion of T-cell clones that recognize common antigens. It is unknown whether these antigens are tumor-derived to which T cells react, or microbial or auto-antigens that promote expansion of both T cells and the leukemic clone. Ibrutinib inhibits Bruton tyrosine kinase and interleukin-2-inducible kinase and has been shown to modulate the T-cell compartment of patients with CLL.We performed deep sequencing of the TCRβ repertoire (Ada...
Source: Blood - Category: Hematology Authors: Tags: 641. CLL: Biology and Pathophysiology, excluding Therapy: Overcoming Immunodeficiency in CLL Source Type: research
Johnson &Johnson (NYSE:JNJ) opened its latest life science incubator in New York City, the healthcare giant said today. The 30,000-square-foot JLabs @ NYC is a collaboration between Johnson &Johnson Innovation, New York State and the New York Genome Center. Sited at the genome center in SoHo, the incubator is home to 26 startups and has room for four more, New Brunswick, N.J.-based J&J said. “Johnson &Johnson has deep entrepreneurial roots in New York and we are pleased to see our unique JLabs model applied in this rich ecosystem to foster the creation of new healthcare innovations that have the pote...
Source: Mass Device - Category: Medical Devices Authors: Tags: Funding Roundup Research & Development johnsonandjohnson Source Type: news
This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition. In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harveste...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Up until the first half of the twentieth century, large-scale health disasters were mostly due to natural causes (earthquakes, volcanoes, hurricanes, etc.) or infections (e.g., smallpox, influenza epidemics, cholera). But something peculiar happened as we entered the second half of the century: Health disasters due to natural causes became dwarfed by large-scale health disasters that are man-made. Here’s a list of the Six Worst U.S. Health Disasters of the Last 50 Years, mostly man-made phenomena that have exacted huge tolls: widespread disease, premature death, poorly managed (though nonetheless highly profitable fo...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle autoimmune gluten grain-free grains Inflammation low-carb Weight Loss Source Type: blogs
AbstractVaccines have been valuable tools in the prevention of infectious diseases, and the rapid development of new vectors against constantly mutating foreign antigens in viruses such as influenza has become a regular, seasonal exercise. Harnessing the immune response against self-antigens is not necessarily analogous or as achievable by iterative processes, and since the desired outcome includes leaving the targeted organism intact, requires some precision engineering. In vaccine-based treatment of autoimmunity and cancer, the proper selection of antigens and generation of the desired antigen-specific therapeutic immuni...
Source: Seminars in Immunopathology - Category: Pathology Source Type: research
Conclusions Safe, effective, affordable homeopathic immunizations exist for almost every illness now targeted by unsafe, costly, failed conventional vaccinations. If the goal were to provide protection from disease in a safe manner, why aren’t these safe, inexpensive homeopathic options made available to the public on a large scale? Millions of dollars in healthcare costs would be saved by using a less expensive immunization. Most significant would be the reduction of vaccine-caused diseases including autism, asthma, allergies, autoimmune disorders, diabetes, and cancer. The health of Americans would improve in drama...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Recent Articles Top Stories homeopathic vaccination homeopathic vaccines truth about vaccines Source Type: blogs
Conclusion The vaccination comprises a misguided and unsafe national health care program which claims to prevent disease. Many significant health injuries are associated with vaccinating adults. Government resources are being spent researching and developing new and different vaccinations. Subjecting adults to more vaccinations is likely to cause more health injury and illness. References: http://www.vaccinationcouncil.org/2012/07/05/herd-immunity… http://www.cdc.gov/chronicdisease/overview/ http://www.vaccinationcouncil.org/2011/02/18/60-lab-studies… http://www.cdc.gov/vaccines/schedules/hcp/adult.html...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Recent Articles Top Stories adult vaccination adult vaccines new vaccines shingles vaccine truth about vaccines Source Type: blogs
Contact: Sarah Avery Phone: 919-660-1306 Email:sarah.avery@duke.eduhttps://www.dukehealth.orgFOR IMMEDIATE RELEASE on Wednesday, Aug. 17, 2016DURHAM, N.C. – Molecules that scavenge debris from dying cells appear to halt the cycle of chronic inflammation in lupus, while also enhancing the body’s ability to combat flu, according to Duke Health studies in mice.The molecules, called polymers, have commonly been used in gene-transfer experiments because they bind to the nucleic acid in DNA and RNA. When deployed directly in mice with lupus or an acute flu infection, the polymers home in on the DNA and RNA refuse fro...
Source: DukeHealth.org: Duke Health Features - Category: Pediatrics Tags: Duke Medicine Source Type: news
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