EU Endorses New Measures to Protect Women From Valproate Epilepsy Drug EU Endorses New Measures to Protect Women From Valproate Epilepsy Drug

French regulator ANSM said epilepsy drug valproate would face new restrictions across the European Union to protect pregnant women or of child-bearing age from exposing their babies to possible malformations and developmental problems.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

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(Natural News) Children who are born to mothers who experienced rheumatoid arthritis during their pregnancy are more likely to have epilepsy. As published in the journal of Arthritis Care &Research, the study led by Dr. Line Jølving from the Odense University Hospital carried out a nationwide study of all children born during a 25-year...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
by Luz A. de Wit, Donald A. Croll, Bernie Tershy, Maria Dolores Correa, Hector Luna-Pasten, Paulo Quadri, A. Marm Kilpatrick Cats (Felis catus) are reservoirs of several pathogens that affect humans, includingToxoplasma gondii. Infection of pregnant women withT.gondii can cause ocular and neurological lesions in newborns, and congenital toxoplasmosis has been associated with schizophrenia, epilepsy, movement disorders, and Alzheimer ’s disease. We compared seroprevalence ofT.gondii and risk factors in people on seven islands in Mexico with and without introduced cats to determine the effect of cat eradication and ca...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
AbstractJuvenile myoclonic epilepsy (JME) is both a frequent and a very characteristic epileptic syndrome with female preponderance. Treatment of JME in women of childbearing potential must consider multiple factors such as desire for pregnancy, use of contraception, seizure control and previously used antiepileptic drugs (AEDs). Approximately 85% of cases are well controlled with valproate, which remains the reference AED in JME but is nowadays considered unsafe for the expecting mother and her fetus. The prescription of valproate is now severely restricted in women of childbearing potential but may still be considered, a...
Source: CNS Drugs - Category: Neurology Source Type: research
The objective of the study was to explore trial of labor and its failure in pregnancies with medical risk conditions, in a population with a high trial of labor rate.Material and methodsIn a cohort study (n=57  109), using data from the Medical Birth Registry of Norway 1989‐2014, women with a second delivery after a first pregnancy cesarean section were included. Preterm, multiple, and non‐cephalic deliveries were excluded. The outcomes were trial of labor and failed trial of labor, assessed as rates and relative risk, using deliveries without risk conditions as reference. Temporal trends were assessed by three‐...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Original Research Article Source Type: research
Abstract PURPOSE OF REVIEW: To summarize recent research findings and current concepts related to care of neurologic diseases in pregnancy and the risks of pregnancy to the mother-infant dyad. Recent publications related to best practices for neurologic care, risks of pregnancy, rate of relapse during and after pregnancy, as well as medication safety in pregnancy and lactation for more commonly used neurologic medications are reviewed. RECENT FINDINGS: Data continues to grow that women with neurologic conditions can experience pregnancy with minimal risks. Additionally, as more data is being published on medi...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Opin Obstet Gynecol Source Type: research
Abstract Epilepsy affects 65 million people worldwide, and is a leading neurologic cause of loss of quality-adjusted life years. The diagnosis of seizures and epilepsy often depends on a careful history, and is supported with electroencephalogram and imaging. First-line treatment of epilepsy includes medical management. Antiepileptic drugs must be chosen with the patient's particular comorbidities in mind. Drug-resistant epilepsy cases should be referred to an epilepsy specialist and may be evaluated for additional medications, epilepsy surgery, neurostimulation, or dietary therapy. When caring for women, provider...
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Med Clin North Am Source Type: research
Purpose: Plasmodium falciparum is the most fatal strain cause severe infection and death especially in children and pregnant women. 80% of malaria deaths in Africa occur in pregnant women and children below 5 years. Cerebral malaria (CM) in children is the most severe neurological complication of infection with Plasmodium falciparum and it is a leading cause of childhood neuro-disability in surviving children who have an increased risk of epilepsy with behavioral difficulties. Pregnancy associated malaria (PAM) is more severe and more fatal due to puerperal sepsis includes cerebral malaria, fever illness and mortality can ...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.153 Source Type: research
ConclusionRAA can be detected by fetal echocardiography and it is associated with other cardiac or non-cardiac abnormalities, 22q11 microdeletion, trisomy 21, and other chromosomal abnormalities. karyotyping should be offered in any case of RAA, irrespective of co-existing malformations. Fetal MRI is a promising diagnostic tool for assessment of congenital cardiovascular abnormalities and extracardiac anomalies.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
In this report, we examine fetal AED exposure effects on learning and memory functions in 221 six-year-old children (including four sets of twins) whose mothers took one of these AEDs during pregnancy. Their performance was compared with that of a national sample of normally developing six year olds from the standardization sample of the Children's Memory Scale (CMS). The major results of this study indicate that the mean performance levels of children exposed to valproate were significantly below that of the children in the normal comparison group across all seven of the CMS Indexes. With one exception, this finding held ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
We present the case of a 24-year-old female who was 4  days post-partum and presented with headache, neck pain, and new-onset seizures. She had undergone epidural anesthesia during labor, and initial imaging was suggestive of intracranial hypotension versus pachymeningitis. Despite initial conservative therapy including anti-epileptic drugs, magnesium therapy, empiric antibiotics, and Trendelenburg positioning, the patient continued to deteriorate. Follow-up imaging was suggestive of PRES with signs of intracranial hypertension. The patient underwent a decompressive suboccipital craniectomy for refractory and severe P...
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
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