Evaluation of XRCC1 Gene Polymorphism as a Biomarker in Head and Neck Cancer Patients Undergoing Chemoradiation Therapy.
CONCLUSIONS: Polymorphic variant XRCC1 HNSCC patients treated with CCRT have significantly increased acute radiation morbidities and may have a trend toward better PFS in comparison with the wild variant. PMID: 29893275 [PubMed - in process]
Authors: Villena-Suarez JR, Vicente W, Taxa L, Cuéllar L, Nuñez-Butrón MT, Villegas V, Castillo M, Castañeda CA Abstract Tuberculosis (TB) is a major public health problem that, due to the clinical variability of its presentation, can be confused with cancer. The aim of this study was to identify the clinical-radiological characteristics and to describe the methodology that allowed to achieve a TB diagnosis in patients referred to the National Institute of Neoplastic Diseases (INEN) with a presumed diagnosis of cancer between 2014 and 2016. The study included 170 patients (52.4% men) wit...
CONCLUSIONS. : Neoadjuvant therapy with dose-dense carboplatin and paclitaxel achieved an elevated frequency of optimal cytoreduction. The post-surgery levels of carcinoembryonic antigen 125 and optimal cytoreduction were independent factors of progression-free survival and overall survival. PMID: 29924276 [PubMed - in process]
Researchers from the Fred Hutchinson Cancer Research Center, Washington, found that unprocessed meats, such as steak, are more strongly linked to the condition than bacon.
A new studyhas found that false positive breast cancer biopsies are costing healthcare facilities over $2.1 billion annually. This high false positive rate and the consequential expenses highlight the need for improved breast cancer diagnostic protocols and technology.Researchers from IBM Watson Health and Seno Medical looked at health care claims filed between 2011 and 2015 from 875,000 women to understand the rate of follow-up procedures after mammography and breast exams. They found that between 2012 and 2015, 8,732,909 patients received diagnostic mammograms, 6,987,399 underwent breast ultrasounds, and 1,585,856 ...
Researchers recently published a study on attitudes to longevity that is reminiscent of the 2013 Pew survey. When asked, people want to live a little longer than their neighbors, at the high end of the normal life span for old individuals today. When asked how long they want to live given the guarantee of perfect health, people pick a number close to the maximum recorded human life span. This sounds like a collusion between the instinctive desires for first conformity and secondly hierarchy, deeply entwined with the human condition, present in all of our primate cousins, a self-sabotaging gift from our evolutionary heritag...
Patients with hepatocellular carcinoma who have high levels of a protein linked to a poor prognosis derive a significant survival benefit with ramucirumab, the results of a pooled analysis reveal.Medscape Medical News
Researchers from the Institute of Cancer Research, London, found that carrying too little weight between the ages of 18 and 24 is particularly risky. Women should not deliberately gain weight.
Barrett ’s esophagus is a known risk factor for esophageal adenocarcinoma. Current clinical practice guidelines recommend endoscopic surveillance for Barrett’s esophagus patients to allow early detection of dysplasia or carcinoma, but endoscopic surveillance of Barrett’s esophagus is inefficient. Risk stratification of patients might improve the effectiveness of surveillance. In this issue of Clinical Gastroenterology and Hepatology, Krishnamoorthi and colleagues1 reported results of a systematic review and meta-analysis of 20 cohort studies including approximately 75,000 patients and found incr easing ag...
Former Puma Biotechnology executive, Robert Gadimian, was sentenced to prison for illegally trading on inside information about a breast cancer drug.
Conclusion: The chloroform fraction from the 95% ethanolic extract of dried leaves was the most effective fraction against bile duct and colon cancer cell lines, thus this extract should be further investigated for active compounds possessing those observed cytotoxic activity. PMID: 29919996 [PubMed]
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