Evaluation of XRCC1 Gene Polymorphism as a Biomarker in Head and Neck Cancer Patients Undergoing Chemoradiation Therapy.
CONCLUSIONS: Polymorphic variant XRCC1 HNSCC patients treated with CCRT have significantly increased acute radiation morbidities and may have a trend toward better PFS in comparison with the wild variant. PMID: 29893275 [PubMed - in process]
Authors: Charytoniuk T, Małyszko M, Bączek J, Fiedorczyk P, Siedlaczek K, Małyszko J Abstract Nephrectomy, which constitutes a gold-standard procedure for the treatment of renal-cell carcinoma (RCC), has been widely discussed in the past decade as a significant risk factor of the development of chronic kidney disease (CKD). RCC is the third most common genitourinary cancer in the United States, with an estimated more than 65,000 new cases and 14,970 deaths. The aim of this review was to precisely and comprehensively summarize the status of current knowledge in chronic kidney disease risk factors after nephrectom...
Authors: Russo Picasso MF, Vicens J, Giuliani C, Jaén ADV, Cabezón C, Figari M, Gómez Saldaño AM, Figar S Abstract Background: Two hypotheses attempt to explain the increase of thyroid cancer (TC) incidence: overdetection by excessive diagnostic scrutiny and a true increase in new cases brought about by environmental factors. Changes in the mechanism of detection and the risk of incidentally diagnosed TC could result in an increase of TC incidence. Methods: Retrospective cohort study. We identified incident cases of TC from the pathological reports of patients in a HMO and review of ...
Contributors : Ting La ; Xu D ZhangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusTo investigate miRNAs in quiescent cancer cell
(MedPage Today) -- Also, breast-conserving surgery or mastectomy?
(Reuters Health) - People with diabetes are more likely to develop certain cancers than those without the condition, and a new analysis suggests that the increased risk is greater for women than for men.
Publication date: Available online 15 August 2018Source: SteroidsAuthor(s): Julius Fink, Masahito Matsumoto, Yoshifumi TamuraAbstractSedentary lifestyle and over-nutrition are the main causes of obesity and type 2 diabetes (T2D). However, the same causes are major triggers of hypogonadism. Many T2D patients show low testosterone levels while hypogonadal men seem to be prone to become diabetic. Testosterone plays a major role in the regulation of muscle mass, adipose tissue, inflammation and insulin sensitivity and is therefore indirectly regulating several metabolic pathways, while T2D is commonly triggered by insulin resi...
(Reuters Health) - Cancer patients who use alternative, non-medical therapies may be more likely to forgo recommended medical treatments like chemotherapy and radiation, and be more likely to die as a result, a U.S. study suggests.
Authors: Millan C, Vivanco JF, Benjumeda-Wijnhoven IM, Bjelica S, Santibanez JF Abstract In orthopedic medicine, a feasible reconstruction of bone structures remains one of the main challenges both for healthcare and for improvement of patients' quality of life. There is a growing interest in mesenchymal stem cells (MSCs) medical application, due to their multilineage differentiation potential, and tissue engineering integration to improve bone repair and regeneration. In this review we will describe the main characteristics of MSCs, such as osteogenesis, immunomodulation and antibacterial properties, key parameter...
Conclusion: Our study shows that, for patients treated withBRAF-V600 + MEK inhibitors who lose response, disease progression was aggressive and had poor outcomes. Most patients had CNS metastases and low rates of therapeutic response to any subsequent therapy.Dermatology
In conclusion, it remains unclear whether AD is a risk factor for metabolic syndrome and its components. However, data indicate that central obesity is associated with AD and that the association is stronger for women than men.Dermatology
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