Signs a child is drowning can be easy to miss

A water safety expert says drowning can happen quickly and without the telltale signs you might expect
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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This study aimed to investigate whether this facilitation of the spinal motoneuron pool excitability by C-TMS is affected by cerebellar transcranial direct current stimulation (ctDCS) in a polarity-specific manner. Eleven healthy adults participated in this study. The H-reflex was measured from the right soleus muscle by electrical stimulation of the right tibial nerve. The conditioning TMS over the right cerebellum was delivered 110 ms before tibial nerve stimulation. The H-reflex ratio was calculated as conditioned/unconditioned H-reflex amplitude, and measured for pre- or post-anodal, cathodal, or sham right ctDC...
Source: Neuroscience Research - Category: Neuroscience Source Type: research
In this study, learning and memory were significantly decreased in ADC mice compared with those in WTC mice, whereas exercise improved learning and memory in APP/PS1 transgenic mice. Meanwhile, ADC mice displayed defective mitochondrial function as evidenced by a significant increase in swollen mitochondria and vacuoles, loss of mitochondrial cristae, and decreased ATP levels, as well as an imbalance in mitochondrial fusion and fission as evidenced by significantly increased Drp1 and Mff and decreased Mfn1, Mfn2, and Opa1 in the hippocampus. Interestingly, exercise mitigated mitochondrial dysfunction as evidenced by a sign...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 19 February 2019Source: Neuroscience LettersAuthor(s): Aya Matsusue, Shin-ichi Kubo, Tomoya Ikeda, Naoto Tani, Toshiki Maeda, Masayuki Kashiwagi, Kenji Hara, Brian Waters, Mio Takayama, Natsuki Ikematsu, Takaki IshikawaAbstractMonoamine oxidase A (MAOA) plays important roles in the metabolism of catecholamines and modulates adrenergic, noradrenergic, and dopaminergic signaling. A polymorphic promoter variable number tandem repeat (VNTR) locus (MAOA-uVNTR) is located approximately 1.2 kb upstream from MAOA exon 1. Functional studies revealed that MAOA-uVNTR affects gene expression. ...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 19 February 2019Source: NeuronAuthor(s): Dana M. Darmohray, Jovin R. Jacobs, Hugo G. Marques, Megan R. CareySummaryStable and efficient locomotion requires the precise coordination of movement across the limbs and body. Learned changes in interlimb coordination can be induced by exposure to a split-belt treadmill that imposes different speeds under each side of the body. Here, we demonstrate locomotor learning on a split-belt treadmill in mice. Mouse locomotor adaptation is specific to measures of interlimb coordination, has spatial and temporal components that adapt at different rates, a...
Source: Neuron - Category: Neuroscience Source Type: research
Publication date: Available online 19 February 2019Source: NeuronAuthor(s): Lu Huang, Yue Xi, Yanfang Peng, Yan Yang, Xiaodan Huang, Yunwei Fu, Qian Tao, Jia Xiao, Tifei Yuan, Kai An, Huan Zhao, Mingliang Pu, Fuqiang Xu, Tian Xue, Minmin Luo, Kwok-Fai So, Chaoran RenSummaryLight plays a pivotal role in the regulation of affective behaviors. However, the precise circuits that mediate the impact of light on depressive-like behaviors are not well understood. Here, we show that light influences depressive-like behaviors through a disynaptic circuit linking the retina and the lateral habenula (LHb). Specifically, M4-type melano...
Source: Neuron - Category: Neuroscience Source Type: research
Publication date: Available online 19 February 2019Source: NeuronAuthor(s): Lucy A. McDermott, Greg A. Weir, Andreas C. Themistocleous, Andrew R. Segerdahl, Iulia Blesneac, Georgios Baskozos, Alex J. Clark, Val Millar, Liam J. Peck, Daniel Ebner, Irene Tracey, Jordi Serra, David L. BennettSummaryLoss-of-function mutations in NaV1.7 cause congenital insensitivity to pain (CIP); this voltage-gated sodium channel is therefore a key target for analgesic drug development. Utilizing a multi-modal approach, we investigated how NaV1.7 mutations lead to human pain insensitivity. Skin biopsy and microneurography revealed an absence ...
Source: Neuron - Category: Neuroscience Source Type: research
Publication date: Available online 20 February 2019Source: NeuroscienceAuthor(s): Nao Nakagawa, Toshihiko HosoyaAbstractGap junctions mediate electrical coupling between neurons and modulate their firing activity. In mouse neocortical layer 5, the major types of pyramidal neurons organize into cell type-specific microcolumns that exhibit modular neuronal activity. During cortical development, microcolumn neurons are electrically coupled in a cell type-specific manner at the stage of synaptogenesis, forming a dense network of gap junctions. However, modulation of neuronal activity by the gap junction network has not been ex...
Source: Neuroscience - Category: Neuroscience Source Type: research
In conclusion, differences in both opioid and cannabinoid sensitivity between HA and LA mice could stem from alterations in intracellular second messenger mechanisms involving G-protein activation.
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 5 February 2019Source: NeuroscienceAuthor(s): Amanda Sierra, Adam Denes
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 19 February 2019Source: NeurocomputingAuthor(s): Yanxiang Chen, Guang Wu, Jie Zhou, Guojun QiAbstractMany researches have brought progress in learning a good generative model by combing the advantages of GAN and VAE, where latent space learning is always important for generating high-quality images. But these existing works mainly seek to impose the latent space a given distribution in advance or to obey a Gaussian distribution with KL divergence penalty, which leads to the difficulties of deciding a suitable prior distribution corresponding to different datasets. Thus in this paper we de...
Source: Neurocomputing - Category: Neuroscience Source Type: research
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