Intraoperative Optical Coherence Tomography (MI-OCT) for the Treatment of Corneal Dystrophies.

CONCLUSION: Microscope-integrated, intraoperative optical coherence tomography (MI-OCT) represents a useful supplement to the normal surgical microscope. It is superior to the sole surgical microscope, especially in already severely clouded corneas, and represents a sensible supplement, especially for novel lamellar transplantation procedures. Prospective randomized trials are necessary to increase safety and efficacy when using MI-OCT for different indications. PMID: 29895084 [PubMed - in process]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research

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Publication date: Available online 16 August 2018Source: Stem Cell ReportsAuthor(s): Hana Golan, Rachel Shukrun, Revital Caspi, Einav Vax, Naomi Pode-Shakked, Sanja Goldberg, Oren Pleniceanu, Dekel D. Bar-Lev, Michal Mark-Danieli, Sara Pri-Chen, Jasmine Jacob-Hirsch, Itamar Kanter, Ariel Trink, Ginette Schiby, Ron Bilik, Tomer Kalisky, Orit Harari-Steinberg, Amos Toren, Benjamin DekelSummaryCancer stem cell (CSC) identification relies on transplantation assays of cell subpopulations sorted from fresh tumor samples. Here, we attempt to bypass limitations of abundant tumor source and predetermined immune selection by in ...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 16 August 2018Source: Stem Cell ReportsAuthor(s): Masha Idelson, Ruslana Alper, Alexey Obolensky, Nurit Yachimovich-Cohen, Jacob Rachmilewitz, Ayala Ejzenberg, Ekaterina Beider, Eyal Banin, Benjamin ReubinoffSummaryAge-related macular degeneration is caused by dysfunction and loss of retinal pigment epithelium (RPE) cells, and their transplantation may rescue visual functions and delay disease progression. Human embryonic stem cells (hESCs) may be an unlimited source of RPE cells for allotransplantation. We analyzed the immunomodulatory properties of hESC-derived RPE (hESC-RPE) cells, and...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 16 August 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Sebastian Kallus, Bernhard Englinger, Julia Senkiv, Anna Laemmerer, Petra Heffeter, Walter Berger, Christian R. Kowol, Bernhard K. KepplerAbstractFibroblast growth factor receptor (FGFR) inhibitors like ponatinib and nintedanib are clinically approved for defined cancer patient cohorts but often exert dose-limiting adverse effects. Hence, we encapsulated FGFR inhibitors ponatinib, PD173074, and nintedanib into polylactic acid nanoparticles and liposomes to enable increased tumor accumulation/specificity and...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Cancer Medicine, EarlyView.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Source Type: research
We examined the incidence and prevalence of ESRD due to scleroderma in Europe and the outcomes among these patients following initiation of RRT.Study DesignRegistry study of incidence and prevalence and a matched cohort study of clinical outcomes.Setting &ParticipantsPatients represented in any of 19 renal registries that provided data to the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry between 2002 and 2013.PredictorScleroderma as the identified cause of ESRD.OutcomesIncidence and prevalence of ESRD from scleroderma. Recovery from RRT dependence, patient survival aft...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Conclusions: In patients with FIP, PVR is a significant contributor of 6MWD, independently from the extent of fibrosis on HRCT. These results strengthen both the rationale to use 6MWD as endpoint in FIP and to target APH with specific therapies.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
This study aimed to analyze the treatment efficacy of ASCT in a Taiwanese cohort and evaluate possible prognostic factors.MethodsFrom the database of the Taiwan Blood and Marrow Transplantation registry, data on 396 patients with MM who underwent ASCT were reviewed.ResultsThe average age of participants was 54.8 years, and there were more men than women (57.6% vs. 42.4%). Most patients were diagnosed with IgG-type myeloma (52.4%), followed by IgA-type (23.2%) and light-chain type (21.4%). Patients with Durie Salmon Staging System (DSS) III disease accounted for 61.9% of the study cohort, while 23.7% had stage II and 14.4% ...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Condition:   Liver Transplant; Complications Interventions:   Drug: N-Acetylecysteine;   Drug: Placebo Sponsor:   Ain Shams University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   IgA Nephropathy Intervention:   Biological: Fecal microbiota transplantation Sponsor:   Fourth Military Medical University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   End Stage Liver Disease;   Acute Kidney Injury Intervention:   Other: Observational study, Beta blocker medication history Sponsor:   Asan Medical Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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