Intraoperative Optical Coherence Tomography (MI-OCT) for the Treatment of Corneal Dystrophies.

CONCLUSION: Microscope-integrated, intraoperative optical coherence tomography (MI-OCT) represents a useful supplement to the normal surgical microscope. It is superior to the sole surgical microscope, especially in already severely clouded corneas, and represents a sensible supplement, especially for novel lamellar transplantation procedures. Prospective randomized trials are necessary to increase safety and efficacy when using MI-OCT for different indications. PMID: 29895084 [PubMed - in process]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research

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Authors: Bachmann BO, Pleyer U, Maier PC, Reinhard T, Seitz B, Cursiefen C Abstract Surgical trauma, and foreign material - such as sutures or implants or antigens during tissue transplantation - may cause inflammatory reactions. Inflammatory reactions after surgical interventions distant from the vascularised limbus and without opening of the anterior chamber of the eye are usually very muted, because of the corneal immune and angiogenic privilege. A milestone in the therapy and prophylaxis of inflammation after corneal surgery has been the use of topical glucocorticoids since the 1950s. When these are used, it is...
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Conclusions: Two patients received successful DMEK grafts using tissues from donors with a history of RK. Careful eye bank screening and processing of RK donor tissues has thus far yielded similar outcomes in our recipient patients to what would be expected using tissues from donors without a history of RK.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
Bone Marrow Transplantation, Published online: 14 May 2019; doi:10.1038/s41409-019-0551-zHaemopoietic cell transplants, corneal transplants and champagne
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Although the Descemet Endothelial Thickness Comparison Trial (DETECT) showed better visual acuity with a newer, more demanding corneal transplantation method, this did not translate into greater patient satisfaction, according to a secondary analysis of outcome data.Reuters Health Information
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Ophthalmology News Source Type: news
AbstractPurposeTo investigate the feasibility of intrastromal lenticule insertion to restore corneal shape in a model of ectatic human cornea.MethodsFor this experimental ex vivo study on 34 human corneas unsuitable for transplantation, 17 corneas were thinned by decentralized posterior excimer laser ablation to 200  μm thickness and 6.5 mm diameter and then inflated up to 100 mm Hg to expose the ectasias (recipient corneas). Pachimetry and topography were obtained. Stromal lenticules of the same diameter and thickness as the ectasias were shaped with a femtosecond laser from the remaining 17 donor cornea...
Source: International Ophthalmology - Category: Opthalmology Source Type: research
CONCLUSIONS: Due to the potential severity of ocular GvHD with immobilisation of the patients and the imminent loss of sight, further improvements in eye care are required. For example, offers such as special consultations, with expertise located close to any transplantation unit are recommended. This requires in particular ophthalmologists to participate in the patient care to enhance quality of life after allo-SCT. In summary, we conclude that the present structures are not sufficient to treat all patients suffering from ocular GvHD in Germany, but the situation has evidently improved. PMID: 31075805 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
We describe a rapid and easy technique for the preparation of pre-stripped Descemet membrane (DM) endothelial keratoplasty (DMEK) tissue in the eye bank, without the use of dye or trephining by the eye bank technician. After drawing 2 radial marks 90 ° apart on the scleral rim of the cornea, a circumferential incision was made internal to the trabecular meshwork and the edge of the DM opposite to the marked area was scored and gently peeled towards the marked area. Finally, the peeled DM was gently unrolled and attached to the posterior stromal bed via absorbing excess liquid from the periphery. The prepared DMEK tissu...
Source: Cell and Tissue Banking - Category: Stem Cells Source Type: research
It has been shown experimentally in rodents that removal of the spleen leads to increased rejection of corneal allografts after corneal transplantation (keratoplasty).
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Case report Source Type: research
Précis: This is a retrospective study with long-term follow-up using transscleral cyclodiode laser photocoagulation (TCP) with low complication rate and good graft survival and intraocular pressure (IOP) control. Selective 180-degree TCP may offer a good IOP control with reduced complication rates. Purpose: To study the long-term safety and efficacy of contact TCP in eyes with refractory glaucoma after penetrating keratoplasty (PKP). Patients and Methods: All consecutive patients who were treated with TCP for refractory glaucoma following PKP between March 1996 and February 2017 in a tertiary corneal transpl...
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
To investigate factors that influence graft failure after Descemet membrane endothelial keratoplasty (DMEK) based on transmission electron microscopy results. Retrospective observational case series. This single center study included 16 eyes of 16 patients with penetrating keratoplasty (n = 14) or repeat DMEK (n = 2) following graft failure after DMEK. The main outcome measures were ultrastructural changes in the explanted graft on transmission electron microscopy, best-corrected visual acuity, and central corneal thickness. The mean preoperative and postoperative best-corrected visual acuity was 1.01 ±...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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