Geisel Receives Fogarty Grant to Fund Research Collaboration in East Africa
The Geisel School of Medicine has been awarded a 5-year, $1.5 million grant from the Fogarty International Center at the National Institutes of Health to support an infectious disease research and training program to combat HIV and tuberculosis (TB) within the newly established Infectious Disease Institute at Muhimbili University of Health and Allied Sciences (MUHAS) in Dar es Salaam, Tanzania.
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Authors: Zhou SH, Wang X, Fan MY, Li HL, Bian F, Huang T, Fang HY Abstract The present study investigated the effects of vitamin D deficiency on T cell subsets in patients with spinal tuberculosis. In addition, the influence of vitamin D deficiency was investigated on the expression of cytokines IL-1β, IL-6 and TNF-α in intervertebral disc lesions of patients. One hundred and seventeen patients with spinal tuberculosis who received operative treatment in the Department of Orthopedics in Wuhan City Third Hospital from March 2012 to March 2015 were collected. The patients were divided depending upon vitami...
ConclusionsA history of asthma or sinonasal disease may modulate immunological response to reduce incidence of active TB in the adult population.
ConclusionsThis study represents the first effort to investigate whole genomes of Philippine clinical strains of MTB exhibiting various profiles of multi-drug resistance. Whole genome data can provide valuable insights to the mechanistic and epidemiological qualities of tuberculosis in a high burden setting such as the Philippines.
Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application. J Immunol Res. 2018;2018:5081634 Authors: Zhao Y, Lin L, Xiao Z, Li M, Wu X, Li W, Li X, Zhao Q, Wu Y, Zhang H, Yin J, Zhang L, Cho CH, Shen J Abstract γδ T cells, a subgroup of T cells based on the γδ TCR, when compared with conventional T cells (αβ T cells), make up a very small proportion of T cells. However, its various subgroups are widely distributed in different parts of the human body and are attractive effectors for infectious disease immunity. &...
[Daily News] WHILE some scientists in the country are taxing brain to come up with child-friendly diagnostic test for Tuberculosis (TB), a recent study shows that trained rats increase the detection of the disease in children significantly and could help address the childhood TB diagnosis challenges.
Publication date: Available online 18 August 2018Source: Life SciencesAuthor(s): Yi Jiang, Haican Liu, Xiangfeng Dou, Xiuqin Zhao, Machao Li, Guilian Li, Yun Bai, Wen Zhang, Lulu Lian, Qin Yu, Jingrui Zhang, Kanglin WanAbstractMycobacterium tuberculosis is the most successful pathogen with multiple mechanisms to subvert host immune response, resulting in insidious disease. There are few studies on whether the bacteria undergo antigenic variation in response to host immune pressure. Studies on T cell epitopes of M. tuberculosis can help us further understand the mechanism of interaction between the bacteria and host immune ...
This article revises the current scenario of the disease's physiopathology and underscores clinicopathological challenges, due to multifaceted presentations of cutaneous tuberculosis, in the diagnosis. PMID: 30111996 [PubMed]
Contributors : Rafick-Pierre Sekaly ; Ali Filali-Mouhim ; Khader Ghneim ; Yueh-hsiu Chien ; Roshni R Chowdhury ; Francesco Vallania ; Qiantian Yang ; Cesar J Lopez Angel ; Fatoumatta Darboe ; Adam Penn-Nicholson ; Virginie Rozot ; Elisa Nemes ; Stephanus Malherbe ; Katharina Ronacher ; Gerhard Walzl ; Willem Hanekom ; Mark M Davis ; Jill Winter ; Xinchun Chen ; Thomas J ScribaSeries Type : Expression profiling by arrayOrganism :Time-course expression analysis profiling whole blood samples collected from healthy South African adolescents while monitoring their potential acquisition of a Mycobacterium tuberculosis infection.
CONCLUSIONS These results suggest that high concentrations of extracellular histones are markedly present in TPE, which may play an inflammatory role towards the progression of tuberculosis. PMID: 30113021 [PubMed - in process]