Geisel Receives Fogarty Grant to Fund Research Collaboration in East Africa
The Geisel School of Medicine has been awarded a 5-year, $1.5 million grant from the Fogarty International Center at the National Institutes of Health to support an infectious disease research and training program to combat HIV and tuberculosis (TB) within the newly established Infectious Disease Institute at Muhimbili University of Health and Allied Sciences (MUHAS) in Dar es Salaam, Tanzania.
Journal Name: Reviews on Environmental Health Issue: Ahead of print
Publication date: Available online 15 October 2018Source: Medical Journal Armed Forces IndiaAuthor(s): Vibha Dutta, Manu Chopra, Uday Bhanu Kovilapu, G.P.S. Gahlot
Conclusions: TB disease is associated with inflammation and decreased HIV-1 RNA expression relative to the number of infected cells, both before and after viral suppression. Infections present before antiretroviral initiation impact HIV-1 latency.
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.8b00497
In most well studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L,D-transpeptidases (LDTs) are highly abundant. To elucidate the role of these unusual crosslinks, we characterizedMycobacterium smegmatis cells lacking all LDTs. We find that crosslinks generate by LDTs are required for rod shape maintenance specifically at sites of aging cell wall, a byproduct of polar elongation. Asymmetric polar growth leads to a non-uniform distribution of these two types of crosslinks in a single cell. Consequently, in the absence of LD...
Abstract Siderophore–antibiotic conjugates consist of an antibiotic covalently linked by a tether to a siderophore. Such conjugates can demonstrate enhanced uptake and internalisation to the bacterial cell resulting in significantly reduced MIC values and extended spectrum of activity. Phenothiazines are a class of small molecules that have been identified as a potential treatment for multidrug resistant tuberculosis and latent TB. Herein we report the design and synthesis of the first phenothiazine–siderophore conjugate. A convergent synthetic route was developed whereby the functionalised phenothiazine compon...
ConclusionsThe results suggest that DM can significantly increase the odds of developing MDR-TB. Consequently, a more robust TB treatment and follow-up might be necessary for patients with DM. Efforts to control DM can have a substantial beneficial effect on TB outcomes, particularly in the case of MDR-TB.Systematic review registrationPROSPEROCRD42016045692.
Conclusion In this setting, patients with CNS infections present late with severe disease and often associated with advanced HIV infection. Tuberculosis, toxoplasmosis, and cryptococcosis are common. High mortality and long-term morbidity underline the need for service improvements and further study.
ConclusionThe data on use of steroids for abdominal tuberculosis are limited to peritoneal tuberculosis. Although steroids seem to have some benefit in patients of tubercular peritonitis, the poor quality of studies limits the generalisability of the findings.Systematic review registration numberCRD42016047347.