A Novel Early Pregnancy Risk Prediction Model for Gestational Diabetes Mellitus

Conclusions: A first-trimester risk prediction model, which incorporates novel maternal lipid markers, accurately identifies women at high risk of GDM, including early GDM.Fetal Diagn Ther
Source: Fetal Diagnosis and Therapy - Category: Perinatology & Neonatology Source Type: research

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Gestational diabetes mellitus (GDM) affects approximately 1-24% of pregnancies [1]. It is defined as glucose intolerance that is recognized for the first time during pregnancy [2]. GDM is associated with adverse complications for the mother (pre-eclampsia, cesarean section) and the fetus (dystocia, large for gestational age, and macrosomia) [3-5]. Early prediction of GDM can lead to appropriate interventions such as lifestyle changes or pharmacological means to reduce adverse health impact. There is no standard agreed-upon screening protocol for GDM.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Tags: Review Source Type: research
Publication date: Available online 2 May 2019Source: Pharmacological ResearchAuthor(s): José Luiz de Brito Alves, Yohanna de Oliveira, Nara Nóbrega Crispim Carvalho, Raíssa Georgianna Silva Cavalcante, Marília Marques Pereira Lira, Luciana Caroline Paulino do Nascimento, Marciane Magnani, Hubert Vidal, Valdir de Andrade Braga, Evandro Leite de SouzaAbstractMaternal cardiometabolic disorders, such as gestational diabetes mellitus, pre-eclampsia, obesity, and dyslipidemia, are the most common conditions that predispose offspring to risk for future cardiometabolic diseases, needing appropriate ther...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Marjon E. Feenstra1†, Mirthe H. Schoots2†, Torsten Plösch1, Jelmer R. Prins1, Sicco A. Scherjon1, Albertus Timmer2, Harry van Goor2 and Sanne J. Gordijn1* 1Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 2Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Objective: Management of late fetal growth restriction (FGR) is limited to adequate fetal monitoring and optimal timing of delivery. The Disproportionate Intrauterine Growth Intervention ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Abstract We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence is influenced by estrogenic status: depression, migraine, irritable bowel syndrome and eating disorders. These diseases all have in common a sex-dimorphic prevalence, with women more frequently affected than men. The co-occurrence between these 5-HT-linked diseases suggests that they have common physiopathological mechanisms. In most 5-HT-linked diseases (except for anorexia nervosa and irritable bowel syndrome), a decrease in...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
Conclusionsin a multi-ethnic population, first-trimester fasting plasma glucose levels were not a better predictor of pregnancy complications than HbA1c. Further, an early HbA1c ≥ 5.8% (39.9 mmol/mol) threshold is already associated with an increased risk of macrosomia.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
One in six live births occur in women with diabetes mellitus, of which the most common type, accounting for approximately 87.5% of all diabetes in pregnancy, is gestational diabetes mellitus (GDM). Maternal hyperglycaemia is one of the principle determinants of maternal –fetal complications in pregnancy in GDM. In particular, hyperglycaemia is most commonly associated with increased rates of instrumental and/or operative delivery, pre-eclampsia, increased adiposity, macrosomia and infant birthweight>90th percentile.
Source: Medicine - Category: Internal Medicine Authors: Tags: Diabetes in patient subgroup Source Type: research
Publication date: Available online 13 December 2018Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Mohammed Bashir, Zeinab Dabbous, Khaled Baagar, Fadi Elkhatib, Amin Ibrahim, Sanam-Alhouda Brich, Manar E. Abdel-Rahman, Justin C. Konje, Abdul-Badie Abou-SamraAbstractObjectivesTo study the pregnancy outcomes in women with type 2 diabetes mellitus (T2DM) and to relate these to maternal risk factors.MethodsWe conducted a retrospective study of 419 women with T2DM (index group)- who attended our diabetes in pregnancy clinic at the Hamad Women’s Hospital, Doha, between March 2015 ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
INTRODUCTION: Pregnancy is a risk factor for venous thromboembolism (VTE) and VTE affects 1 in 500 to 1 in 2000 pregnancies. Up to 30-50% of women with pregnancy-associated VTE may have an inherited thrombophilia but this does not completely explain the thrombosis risk. Clinical risk factors for VTE including multiple births, inflammatory bowel disease, sickle cell disease, diabetes, increased maternal age, stillbirth, and smoking have been identified in relatively small cohorts. We conducted this large case-control study to identify patient and pregnancy-associated risk factors for VTE during pregnancy or within 6 weeks p...
Source: Blood - Category: Hematology Authors: Tags: 331. Pathophysiology of Thrombosis: Poster III Source Type: research
Diabetes mellitus is common and complicates 2 –5% of pregnancies in the UK, with an increasing prevalence of pre-existing diabetes mellitus in pregnancy. Hyperglycaemia directly correlates with adverse maternal and fetal outcomes, including congenital anomaly, miscarriage, pre-eclampsia, pre-term delivery, macrosomia, stillbirth and neonatal hypoglycaemia. Optimal glycaemic control before conception and during the antenatal period is paramount to reduce these risks. Pre-pregnancy preparation should focus on glycaemic control, medication review and end-organ disease assessment.
Source: Medicine - Category: Internal Medicine Authors: Tags: Medicine and other specialties Source Type: research
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