Malawi:Foot and Mouth Vaccine Rolls Out

[Malawi News Agency] Blantyre -Affected districts of foot and mouth disease on Saturday got a sigh of relief as government rolled out vaccination of the disease to prevent further occurrence.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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Publication date: Available online 18 August 2018Source: Fish &Shellfish ImmunologyAuthor(s): Craig A. Shoemaker, Haitham Mohammed, Troy J. Bader, Eric Peatman, Benjamin H. Beck
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 17 August 2018Source: BiologicalsAuthor(s): Angela Walker, Renee Olsen, Mindy Toth, Geetha SrinivasAbstractApproximately one-third of the reportable USDA Category D and E laboratory animals in the United States are expended on the potency testing of leptospiral vaccines by the codified hamster vaccination-challenge assay. Valid tests require ≥80% of challenge controls to succumb to disease and an LD50 between 10 and 10,000. This work evaluates the risk associated with the removal of LD50 limits; thereby, eliminating back-titration hamsters from in vivo potency assays for Leptospira (L....
Source: Biologicals - Category: Biology Source Type: research
China said on Saturday it has sacked six senior officials at its food and drug regulator after a safety scandal at vaccine maker Changsheng Biotechnology Co Ltd revealed failings at the government body including inadequate supervision.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Publication date: Available online 17 August 2018Source: Preventive Veterinary MedicineAuthor(s): Zelalem G. Terfa, Supriya Garikipati, Girma Kassie, Judy Bettridge, Rob M. ChristleyAbstractNewcastle disease (NCD) is an important disease of poultry, directly affecting the livelihoods of poor farmers across developing countries. Research has identified promising innovations in NCD vaccine development and field trials among village poultry have been promising. However, NCD vaccination is not currently part of village poultry extension programmes in many developing countries. Understanding the preferences for, and relative im...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Conclusion: According to the findings of the present research, the microbially synthesized Ag-Cu nanoalloy demonstrated antibacterial effects on the majority of the bacteria studied even at 0.01 μg/μL. However, complementary investigations should be conducted into the safety of this nanoalloy for in vivo or systemic use. PMID: 30112155 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
This study was aimed to generate SLEV and WNV NS1 recombinants proteins for the development of a flavivirus diagnostic test. Local Argentinian isolates were used as the source of NS1 gene cloning, expression, and purification. The protein was expressed in Escherichia coli as inclusion bodies and further purified by metal-chelating affinity chromatography (IMAC) under denaturing conditions. Human sera from SLEV and WNV positive cases showed reactivity to the recombinant NS1 proteins by western blot. The unfolded NS1 proteins were also used as immunogens. The polyclonal antibodies elicited in immunized mice recognized the tw...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
AbstractImmunotherapy is rapidly transforming cancer care across a range of tumor types. Although Sipuleucel-T represented the first successful vaccine for the treatment of established cancer, other immunotherapeutic approaches for prostate cancer such as checkpoint inhibitors have been relatively disappointing to date. However, significant promise is on the horizon as there is a wide array trials evaluating immunotherapy in prostate cancer patients. These include both immune checkpoint inhibitors and antigen-specific approaches including vaccines, antibody-drug conjugates, and antitumor antibodies. Furthermore, a better u...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
Intraperitoneal infection ofMycobacterium tuberculosis from BCG vaccine to male BALB/c mice provoked the formation of multinuclear macrophages in the peritoneal transudate. In 2 and 3 months after infection, their number increased respectively by 34.4 and 66.7% in comparison with intact mice. At all postinfection terms, far greater amounts of caspase 3, p53, Bad, and TNF α were expressed by multinuclear macrophages than by the mononuclear ones. At these terms, the content of Bcl-2-expressing macrophages with different numbers of nuclei was pronouncedly high; of them, the number of multinuclear macrophages was maximum...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
Publication date: Available online 15 August 2018Source: Microbial PathogenesisAuthor(s): César Luis Medrano-Díaz, Arturo Vega-González, Estela Ruiz-Baca, Abel Moreno, Mayra Cuéllar-CruzAbstractIn recent years, C. albicans and C. glabrata have been identified as the main cause of candidemia and invasive candidiasis in hospitalized and immunocompromised patients. In order to colonize the human host, these fungi express several virulence factors such as the response to oxidative stress and the formation of biofilms. In the expression of these virulence factors, the cell wall of C. albicans and C. ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 14 August 2018Source: Microbial PathogenesisAuthor(s): Min Yong Jwa, Eun Byeol Ko, Hyun Young Kim, Sun Kyung Kim, Soyoung Jeong, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun HanAbstractStreptococcus pneumoniae is a major respiratory pathogen that can cause pneumonia, meningitis, and otitis media. Although capsular polysaccharide-based vaccines are commercially available, there is a need for broad-spectrum, serotype-independent, and cost-effective vaccines. Recently, an intranasal vaccine formulated with gamma-irradiated nonencapsulated S. pneumoniae whole cells has been developed and its immu...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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