Regional Registry-based Biobank Development and Pharmacogenetic Analysis in Rheumatoid Arthritis

Condition:   Rheumatoid Arthritis Intervention:   Other: Biobank creation and Pharmacogenetic analysis Sponsors:   Istituto Ortopedico Rizzoli;   Regione Emilia Romagna - Italy within PRU-Liberati project Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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ConclusionIt is the first COPCORD study in an urban native population living at high altitude in Peru. The population affected by chronic rheumatic disease preferred professional rather than traditional care; this population had access to limited medical services. Impaired functional capacity measured by HAQ was associated with advanced age.ResumenObjetivoEstimar la prevalencia de manifestaciones musculoesqueléticas y discapacidad en la población urbana habitante a gran altura de Juliaca, Puno, Perú; utilizando el cuestionario COPCORD y HAQ-DI.MétodosSe realizó un estudio transversal en m...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
This study identified effective extracts from Eucommia ulmoides Oliv. relieving immune inflammation and maintaining structural integrity of joints in CIA rats. PMID: 30105062 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
CONCLUSIONS Both pro-inflammatory cytokines (TNF-α and IL-6) and anti-inflammatory mediators (TIM-3 and IL-37) simultaneously contribute to the pathogenesis of RA. TIM-3 and IL-37 may be used as potential biomarkers of active RA. PMID: 30106887 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Study Design. Retrospective review. Objective. To identify the incidence and analyze the risk of postoperative complications amongst elderly patients with rheumatoid arthritis undergoing anterior cervical fusion. Summary of Background Data. Previous studies have reported elevated risks of postoperative complications for patients with rheumatoid arthritis undergoing orthopedic procedures. However, little is known about the risk of postoperative complications in rheumatoid arthritis patients after spine surgery. Methods. A commercially available database was queried for all Medicare patients 65 years of age and ol...
Source: Spine - Category: Orthopaedics Tags: Surgery Source Type: research
What benefits might sarilumab monotherapy offer over adalimumab monotherapy in the treatment of rheumatoid arthritis?Arthritis Research &Therapy
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
This study also highlights the dynamic potential of aloin as a therapeutic agent to treat osteope nic disorders.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research
NEW YORK (Reuters Health)—Tumor necrosis factor (TNF) inhibitors do not appear to increase cancer-recurrence rates in patients with rheumatoid arthritis (RA), according to new findings from Sweden. TNF has both tumor-promoting and cancer-protective effects, so TNF inhibitors could conceivably affect the risk for cancer recurrence. However, few studies have reported the risk for cancer relapse... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Rheumatoid Arthritis Cancer Rheumatoid Arthritis (RA) TNF inhibitors Source Type: research
Condition:   Rheumatoid Arthritis (RA) Intervention:   Diagnostic Test: Vectra DA Sponsor:   Myriad Genetic Laboratories, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractThe aim of this study was to examine whether the vitamin D level is causally associated with risk of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). We performed two-sample Mendelian randomization (MR) analyses using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods on publicly available summary statistics datasets using two vitamin D level genome-wide association studies (GWASs) as exposure and SLE and RA GWASs on people of European descent as outcomes. We selected three independent single-nucleotide polymorphisms located at SSTR4 (rs2207173), GC (rs2282679), an...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
This study aimed to assess the incidence of active TB and the efficacy of TB prevention measures used over the years, and to determine risk factors for developing TB, in a single-centre cohort of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) receiving TNFi. Data of all patients in whom treatment with TNFi was initiated in our rheumatology clinic until December 1st 2014 have been retrospectively analysed. The cohort was divided into 3 groups per the mandatory LTBI screening method at baseline: tuberculin skin test (TST) with a positive threshold of either 10  mm (gro...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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