Regional Registry-based Biobank Development and Pharmacogenetic Analysis in Rheumatoid Arthritis
Condition: Rheumatoid Arthritis Intervention: Other: Biobank creation and Pharmacogenetic analysis Sponsors: Istituto Ortopedico Rizzoli; Regione Emilia Romagna - Italy within PRU-Liberati project Recruiting
In this study, a collagen-induced arthritis (CIA) model was established to simulate rheumatoid arthritis (RA) using two intradermal injections of bovine type II collagen and Freunds complete adjuvant mixture given at two-week intervals. Subsequently, the transplantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) was used to treat RA and the treatment efficacy, as well as the possible regulatory mechanism underlying hUC-MSC transplantation, was observed. During the study, forty rats were randomly divided into four groups and their blood samples were collected at different time points to measure levels of se...
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No abstract available
The role of neutrophil extracellular traps in rheumatic diseases, Published online: 21 June 2018; doi:10.1038/s41584-018-0039-zA growing body of evidence indicates that neutrophils and neutrophil extracellular traps (NETs) are involved in the progression of rheumatic diseases. This Review focuses on the role of NETs in systemic lupus erythematosus, vasculitis, rheumatoid arthritis and gout.
A new study shows how rheumatoid arthritis inflammation affects different brain areas. The findings may explain the cognitive symptoms of the condition.
Penicillamine is a drug that is used to treat Wilson ’s disease, rheumatoid arthritis, and kidney and bladder stones. It can have serious side effects, so it is important to follow the doctor’s instructions and to attend all follow-up appointments to monitor for any changes while taking this drug. Find out more.
Conclusions: Both MSCs-derived MPs and Exos exerted an anti-inflammatory role on T and B lymphocytes independently of MSCs priming. However, Exos were more efficient in suppressing inflammation in vivo. Our work is the first demonstration of the therapeutic potential of MSCs-derived EVs in inflammatory arthritis.
What benefits might tofacitinib offer rheumatoid arthritis patients? How does it compare to other treatment options?Arthritis Research &Therapy
Menopause may be associated with accelerated functional decline among women with rheumatoid arthritis, a new study suggests.Rheumatology
This study assessed the therapeutic effects of ferulic acid on osteoclast differentiation and bone erosion by targeting RANKL dependent NF-κB pathway. Main methods RAW 264.7 monocyte/macrophage cells were left untreated/treated with 25, 50 and 100 μM ferulic acid prior to stimulation with/without RANKL and M-CSF. Osteoclast differentiation and formation was assessed by SEM and TRAP analysis whereas its functional activity of bone erosion was determined by pit formation assay. Crucial transcription factors (NF-κBp-65, NFATc1 and c-Fos) and osteoclast specific genes (TRAP, MMP-9 and Cathepsin K) were evaluat...