Correlation of human papillomavirus infection and clinical parameters with five-year survival in oral squamous cell carcinoma.

CONCLUSION: There is a high prevalence of HPV positive oral squamous cell carcinoma in Pakistan; however, there is no difference in the five-year survival rate when compared to HPV negative oral squamous cell carcinoma. PMID: 29888686 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

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Authors: Yang H, Cao Y, Li ZM, Li YJ, Jiang WQ, Shi YX Abstract Cyclin-dependent kinase inhibitor 2A (p16INK4a) protein is a surrogate immunohistochemical marker of human papillomavirus infection in oropharynx squamous cell carcinoma (OPSCC). However, the effects of p16INK4a in non-OPSCC require additional analysis. In addition, major gaps remain in the literature, including small volumes of data for China. Therefore, the present study evaluated the frequency of p16INK4a positivity in patients with non-OPSCC in Southern China, and assessed its prognostic value. p16INK4a expression status in patients with non-OPSCC ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
With every passing year, more and more studies and observations demonstrate growing incidence of oral cancer, a decrease in patients’ age, and an increasing number of epidemiological factors. The aim of the study was to determine the level of awareness among undergraduate and graduate university students regarding the incidence of oral cancer linked with viral infections and high-risk sexual behavior, including oral sex. Self-administered questionnaire-based survey was carried out among 196 Polish students aged 19 to 25 years. It was found that the young adults understood the meaning of human papillomavirus (HPV), bu...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Meta-Analysis of Observational Studies in Epidemiology Source Type: research
Abstract OBJECTIVES: Worldwide studies have shown an increasing trend of oropharyngeal squamous cell carcinoma (OPSCC) but a decreasing trend of oral cavity cancers over the past 2 decades, particularly in developed countries with successful tobacco control. This trend has been attributed to the increase in the incidence of human papillomavirus (HPV)-associated OPSCC. The aim of this study was to examine sex differences in incidence trends of oropharyngeal and oral cavity cancers in Hong Kong from 1983 to 2014. METHODS: Using data from the Hong Kong Cancer Registry from 1983 to 2014, age-standardized incidenc...
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Tags: Ann Otol Rhinol Laryngol Source Type: research
In conclusion, H. pylori was found in the area of laryngeal carcinoma, and its migration appeared likely to occur both upwards (from the stomach to the mouth) and downwards (from the oral cavity to the stomach). PMID: 30256015 [PubMed - in process]
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Tobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in younger patients is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Oral and Maxillofacial Pathology Source Type: research
This study evaluated the integration and methlyation of human papillomavirus type 16 (HPV16) in head and neck squamous cell carcinoma (HNSCC) and its oral precursor, high-grade oral epithelial dysplasia (hgOED). Archival samples of HPV16-positive hgOED (N = 19) and HNSCC (N = 15) were evaluated, along with three HNSCC (UMSCC-1, -47 and -104) and two cervical cancer (SiHa and CaSki) cell lines. HgOED cases were stratified into three groups with increasing degrees of cytologic changes (mitosis, karyorrhexis and apoptosis). The viral load was higher and the E2/E6 ratio lower (indicating a greater tendency toward viral integra...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Over the last two decades, human papillomavirus related (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) has been recognized as a fundamentally different disease than tobacco and alcohol related (HPV −) OPSSC [1–3]. While both diseases are squamous cell carcinomas that arise in the oropharynx, HPV+ disease tends to affect a younger cohort of patients with a different set of risk factors [1–3], and has been shown to have different molecular biology than HPV negative disease [4]. Importantly , patients with HPV+ disease have a substantially improved prognosis [1–3,5].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
This report describes a case of p16-positive tonsillar SCCa with metastasis to a highly unusual seconda ry site in the pleura to show an example of the unconventional patterns of distant metastases reported for HPV-positive oropharyngeal SCCa in the recent literature.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Case Report Source Type: research
ConclusionSubstantial increase in awareness is required among OHP regarding HPV-OSCC link.
Source: Journal of Oral Biology and Craniofacial Research - Category: Dentistry Source Type: research
Conditions:   Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma;   Stage II Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7;   Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7;   Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 Interventions:   Drug: Cyclophosphamide;   Biological: IRX-2;   Biological: Nivolumab;   Procedure: Surgery Sponsors:   Emory University;   Bristol-Myers Squibb;   IRX Therapeutics Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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