Correlation of human papillomavirus infection and clinical parameters with five-year survival in oral squamous cell carcinoma.

CONCLUSION: There is a high prevalence of HPV positive oral squamous cell carcinoma in Pakistan; however, there is no difference in the five-year survival rate when compared to HPV negative oral squamous cell carcinoma. PMID: 29888686 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

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This study evaluated the integration and methlyation of human papillomavirus type 16 (HPV16) in head and neck squamous cell carcinoma (HNSCC) and its oral precursor, high-grade oral epithelial dysplasia (hgOED). Archival samples of HPV16-positive hgOED (N = 19) and HNSCC (N = 15) were evaluated, along with three HNSCC (UMSCC-1, -47 and -104) and two cervical cancer (SiHa and CaSki) cell lines. HgOED cases were stratified into three groups with increasing degrees of cytologic changes (mitosis, karyorrhexis and apoptosis). The viral load was higher and the E2/E6 ratio lower (indicating a greater tendency toward viral integra...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Over the last two decades, human papillomavirus related (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) has been recognized as a fundamentally different disease than tobacco and alcohol related (HPV −) OPSSC [1–3]. While both diseases are squamous cell carcinomas that arise in the oropharynx, HPV+ disease tends to affect a younger cohort of patients with a different set of risk factors [1–3], and has been shown to have different molecular biology than HPV negative disease [4]. Importantly , patients with HPV+ disease have a substantially improved prognosis [1–3,5].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
This report describes a case of p16-positive tonsillar SCCa with metastasis to a highly unusual seconda ry site in the pleura to show an example of the unconventional patterns of distant metastases reported for HPV-positive oropharyngeal SCCa in the recent literature.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Case Report Source Type: research
ConclusionSubstantial increase in awareness is required among OHP regarding HPV-OSCC link.
Source: Journal of Oral Biology and Craniofacial Research - Category: Dentistry Source Type: research
Conditions:   Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma;   Stage II Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7;   Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7;   Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 Interventions:   Drug: Cyclophosphamide;   Biological: IRX-2;   Biological: Nivolumab;   Procedure: Surgery Sponsors:   Emory University;   Bristol-Myers Squibb;   IRX Therapeutics Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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