Correlation of human papillomavirus infection and clinical parameters with five-year survival in oral squamous cell carcinoma.

CONCLUSION: There is a high prevalence of HPV positive oral squamous cell carcinoma in Pakistan; however, there is no difference in the five-year survival rate when compared to HPV negative oral squamous cell carcinoma. PMID: 29888686 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

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CONCLUSION: The prevalence of HNSCC is modest compared with other cancers in HIV-infected individuals. The prevalence of oropharynx carcinoma, a potentially HPV-related carcinoma, seems to increase over time. Even if tobacco may be an important contributor, the role of HPV in HIV-infected individuals presenting with HNSCC should be investigated. PMID: 29887186 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has steadily increased in recent years [1]. High-risk strains of human papillomavirus (HPV) are being recognized as a key driver in this change and are predicted to account for the majority of oropharyngeal carcinomas by 2030 [2 –4]. HPV-positive tumors have greater radio- and chemo-sensitivity which confer more favorable survival rates when compared to HPV-negative tumors [5,6]. Given the fundamental differences in the biology underlying HPV-positive OPSCC, a re-evaluation of traditional treatment algorithms is currently underway in a number of de-intens...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
Authors: Appah EO, Ballard BR, Izban MG, Jolin C, Lammers PE, Parrish DD, Marshall DR Abstract Oral tongue squamous cell carcinoma (OTSCC) has a median age at diagnosis of 62 years. The incidence of OTSCC in young adults has been increasing, and the reason is unclear. The present study describes a case, and molecular analysis, of OTSCC in a 21-year-old female. Clinical and pathological information were collected from medical records. Formalin-fixed paraffin-embedded biopsy tissue from the patient was reassessed using standard hematoxylin &eosin staining, and immunohistochemistry was used to assess the expressio...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
CONCLUSIONS: Results of this study indicate that the association between HPV and OSCC may be overestimated. Hence, multicentric studies covering diverse geographical and socioeconomic groups are needed to delineate the profile of HPV infectivity and OSCC in the Indian subcontinent.
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Human papillomavirus (HPV) is the most common sexually transmitted infection in North America [1,2]. The oncogenic potential of HPV was first described in cervical cancer [3]. More recently, the link between oropharyngeal squamous cell carcinoma (OPSCC) and oral HPV infection was established [4,5]. An estimated 72% of OPSCC cases are associated with HPV in North America [6]. The incidence of OPSCC has been rising rapidly, and has overtaken cervical cancer to become the most common HPV-related cancer in the United States [6,7].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Over the past two decades, an increase in incidence of oropharyngeal squamous cell carcinoma (OPC) has been reported in patients with no history of alcohol and tobacco use. Human papillomavirus type 16 has been identified as the most important etiological agent of this malignancy [1]. Following the standard treatment regimes, patients with HPV-associated tumors have a better clinical outcome than patients with tobacco-related carcinomas; however, standard chemo- and radiotherapy is still associated with considerable morbidity and toxicity in these patients.
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
In this issue ofJAMA Otolaryngology —Head&Neck Surgery, Li et al shows that human papillomavirus –positive squamous cell carcinoma (SCC) may be associated with improved overall survival not only in the oropharynx but also possibly in the upper aerodigestive tract subsites—oral cavity, larynx, and hypopharynx. This finding is persuasive given the large sample size used, which was obtained fr om the National Cancer Database (NCDB), and the multivariate analysis performed. Previous studies with smaller sample sizes have similarly suggested the favorable prognostic role of HPV in cancer in nonoropharyngea...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
Human papillomavirus (HPV) is now acknowledged as a risk factor for oropharyngeal squamous cell carcinoma (OPSCC), where tonsillar and base of tongue cancer (TSCC/BOTSCC) make up most HPV-positive (HPV+) cases, and as causative for the recent increase in the incidence of OPSCC [1 –8]. Of note, HPV+ TSCC/BOTSCC patients treated with radiotherapy alone have better disease-specific-survival (DSS) than those with corresponding HPV-negative (HPV−) cancer, with 80% vs. 40% 3-year DSS [9–14]. Due to poor prognosis in the HPV− group predominantly, head-neck cancer treatment has been intensified in the past ...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
Authors: Ceccarelli M, Rullo EV, Facciolà A, Madeddu G, Cacopardo B, Taibi R, D'Aleo F, Pinzone MR, Picerno I, di Rosa M, Visalli G, Condorelli F, Nunnari G, Pellicanò GF Abstract Over the last 20 years we assisted to an increase in the mean age of People Living with HIV and their comorbidities. Especially, there was an increase in Human Papillomavirus-related head and neck squamous cell carcinomas. Despite their increasing incidence in HIV-positive people, mechanisms that lead to their development and progression are only partially understood. The aim of this review is to identify key data and factor...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusion: This study showed weak positive correlation between mean eosinophils count in tumor and LNs. Recognition of TATE and MCs as integral to tumor biology opens an avenue for novel approaches to cancer therapies. We conclude that an increased number of immunological cells are a favorable prognostic indicator in OSCC.
Source: Journal of Oral and Maxillofacial Pathology - Category: ENT & OMF Authors: Source Type: research
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