Pseudomonas aeruginosa invades human aortic endothelial cells and induces cell damage in vitro.

CONCLUSIONS: In this study, we demonstrate for first time that P. aeruginosa can invade and survive inside HAECs. This cell culture model can be of immense importance to determine the efficacy of drug targets against IE. PMID: 29886837 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

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ConclusionKnowledge levels of guidelines for antibiotic prophylaxis varied greatly depending on the study design, respondent characteristics, and time period factors. There is a lack of research published on compliance rates for dentists and dental students with respect to guidelines for the prevention of infective endocarditis.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
Authors: Pericàs JM, Quintana E, Miró JM PMID: 31737334 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Balla S, Alkhouli M PMID: 31737333 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Kubota H, Endo H, Ishii H, Minegishi S, Tsuchiya H, Takahashi Y, Funata S, Inaba Y PMID: 31737322 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
ConclusionWe demonstrated that high SII levels are independently associated with in-hospital mortality. The SII may be a promising prognostic predictor for patients with infective endocarditis.
Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
This study aimed to analyze the early and mid-term outcomes of aortic valve replacement with bovine pericardium in the treatment of aortic valve regurgitation.From January 2015 to March 2018, 36 patients (19 men; mean ± standard deviation [SD] age, 46.70 ± 16.60 years) underwent aortic valve replacement with bovine pericardium. The bovine pericardium was intraoperatively measured and shaped using an Ozaki template, according to the shape and size of the individual patient's aortic valve leaflets. Additional procedures were performed, including ventricular septal defect repair in 5 cases, mitral valve reconstr...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Abstract Infective endocarditis (IE) is a complex disease with cardiac involvement and multiorgan complications. Its prognosis depends on prompt diagnosis that leads to an aggressive therapeutic management combining antibiotic therapy and early cardiac surgery when indicated. However, IE diagnosis always poses a challenge, and echocardiography remains diagnostically imperfect in cases of prosthetic valve IE or cardiac implantable electronic device infection. In recent years, other imaging modalities (computed tomography, magnetic resonance imaging, nuclear imaging) have experienced significant technical improvemen...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Morbidity and mortality from opioid use disorder (OUD) remain at epidemic levels in the United States. In the 12-month period ending July 2018, approximately 46,000 people died from opioid overdose in the United States, approximately five deaths every hour.[1] The harms of OUD extend beyond the well-publicized overdose deaths. Aside from the tragic toll on families, patients experience social and medical sequelae of drug use. Among the medical sequelae is drug use-associated infective endocarditis, whose incidence has risen dramatically where opioid use disorder (OUD) is endemic; at least one state experienced a tenfold in...
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
AbstractDetection of residual fibrotic tissue, called ghosts, after lead extraction is a new phenomenon in cardiology. This paper aims at describing the phenomenon of ghosts and determining their characteristic features. The study group consisted of 580 consecutive patients who underwent transvenous lead extraction (TLE) due to local infection, endocarditis and a superfluous lead. Each patient was clinically examined with the application of transthoracic echocardiography and transesophageal echocardiography directly before and after TLE. In the study population ghosts were detected in 110 patients (19%), and in 470 cases (...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
AbstractLiver dysfunction is associated with adverse events in infective endocarditis (IE). However, few studies have explored the predictive value of conjugated bilirubin (CB) in IE. We aimed to investigate the nature of the link between CB and adverse prognosis in patients with IE. Consecutive patients with IE between January 2009 and July 2015 were enrolled. Multivariate analysis was performed to confirm whether CB was an independent risk factor for adverse outcomes. In all, 1010 patients were included and divided into two groups according to admission CB level ( μmol/L): normal (≤ 7.0,n = 820...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
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