Cardiology MCQ 326: Omapatrilat

Omapatrilat inhibits:
a) Angiotensin converting enzyme
b) Neprilysin
c) Aminopeptidase P
d) All of the above

["Click here for the answer with explanation", "Correct Answer:"]

d) All of the above

Omapatrilat inhibits angiotensin converting enzyme, neprilysin, and aminopeptidase P [McMurray JJ et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014 Sep 11;371(11):993-1004]. Neprilysin is a neutral endopeptidase which degrades vasoactive peptides like natriuretic peptides, bradykinin and adrenomedullin.

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Source: Cardiophile MD - September 28, 2014 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs