Canonical Wnt pathway gene expression and their clinical correlation in oral squamous cell carcinoma

Conclusion: Wnt3A, β-catenin, and cyclin D1 are recognized as key components of Wnt/β-catenin signaling. However, in this study, there was no significant expression of all the three genes in OSCC. The proto-oncogene c-MYC showed statistically significant upregulation in cancer tissue samples suggesting that the OSCC among South Indian population is primarily not mediated by the canonical Wnt signaling pathway.
Source: Indian Journal of Dental Research - Category: Dentistry Authors: Source Type: research

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Publication date: Available online 23 May 2019Source: Journal of Cancer PolicyAuthor(s): Steve Langton, Derek Lowe, Simon N Rogers, Annette Plüddemann, Clare BankheadAbstractBackgroundThe ‘two-week rule’ (TWR) fast-track cancer referral system for head and neck cancers was introduced by the UK government in 2000, to facilitate earlier diagnosis. However, little work has compared stage on diagnosis of cancer before and after the implementation of the system.Objectives•Describe the presentation of oral cancer in Merseyside from 1992-2012.•To evaluate whether stage on presentation has improved after...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
Publication date: August 2019Source: Cancer Epidemiology, Volume 61Author(s): Upma Sharma, Pallavi Singhal, Kapil Bandil, Rajeshwar Patle, Anoop kumar, Kausar Neyaz, Surojit Bose, Ajay Kumar Dewan, Ravi Mehrotra, Veena Sharma, Mausumi BharadwajAbstractBackground: Despite being most preventable malignancies associated with smoked and smokeless tobacco products, squamous cell carcinoma of oral cavity is one of the most common malignancy in India. The aim of the present study was to evaluate the role of TLRs in oral pre-cancerous, cancerous cases and their genotypic correlation with HPV/EBV, co-infection &lifestyle habits...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Our results suggested the oncogenic role of miR-4513 in OSCC, and therefore it might be used as a target for the OSCC treatment. PMID: 31115009 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Conclusions: TIC is an accurate, simple, rapid, and cost-effective method that aids the diagnosis of oral squamous cell carcinoma but does not replace incisional biopsy. The cytologic examination of imprints of biopsies also helps determine the adequacy of the specimen for histologic examination.Acta Cytologica
Source: Acta Cytologica - Category: Cytology Source Type: research
Authors: Boguñá N, Capdevila L, Jané-Salas E Abstract Over the last few decades, the human papillomavirus (HPV) infection has emerged as a new epidemic and become a health issue due to its involvement in several cancers affecting the cervix, the anogenital region and the oropharynx. In this review, we aim to understand and explain the distinctive features of HPV-related oropharyngeal squamous cell carcinoma based on its epidemiological data, risk factors, specific topography, HPV subtypes most frequently involved, HPV-status diagnosis, clinical behaviour, prognosis, treatment, and preventive me...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
The objective of the present study was to analyze methyl green-pyronin Y (MGP)-stained oral exfoliated cells (OECs) of oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) by cytomorphometry.Materials and Method: An observational study was conducted on 150 individuals equally divided into three groups: normal mucosa, OL, and OSCC. Smears were prepared from OECs and stained with MGP. Cytomorphometry was done for 100 cells per subject, and various cell and nuclear parameters were measured and calculated.Results: The Kruskal-Wallis test with post hoc correlation showed significant differences in nucleus and cell diam...
Source: Acta Cytologica - Category: Cytology Source Type: research
Long non-coding RNAs (lncRNAs) are promising therapeutic molecules of cancer. Here we aim to study the therapeutic effect and mechanism of a lncRNA, HOXA11-AS, in oral squamous cell carcinoma (OSCC).
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
Conclusion: DIE triggers the antimetastatic activity in OSCC cells by suppressing the MMP-2 activity via the MEK/ERK signaling pathways. Therefore, these findings are promising for the use of DIE antimetastatic activity in oral cancer metastasis treatment.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
The optimal surgical margins assessment is capital in oral squamous cell carcinoma (OSCC) management. We evaluated the clinical benefits of integrating intraoperative macroscopic margin (MM) assessment and nar...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Publication date: Available online 15 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Elham Ahmadian, Solmaz Maleki Dizaj, Simin Sharifi, Shahriar Shahi, Rovshan Khalilov, Aziz Eftekhari, Mohammad HasanzadehAbstractOral squamous cell carcinoma (OSCC), a main type of oral cancer, is one of the main causes of morbidity and mortality worldwide. Subsequent to definite diagnosis of oral cancer, generally a multidisciplinary approach is used in OSCC treatment which consists of surgery, chemotherapy and radiation. However, conventional chemotherapeutic agents might be ineffective and induce different side effects. N...
Source: TrAC Trends in Analytical Chemistry - Category: Chemistry Source Type: research
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