Surgical Outcomes of Double Compression And Complete Fixation Bar System in Pectus Excavatum.

Surgical Outcomes of Double Compression And Complete Fixation Bar System in Pectus Excavatum. Ann Thorac Surg. 2018 Jun 08;: Authors: Song IH, Lee SJ, Kim SS, Lee SY Abstract BACKGROUND: Minimaly invasive repair of pectus excavatum (MIRPE) is a widely used technique for correction of pectus excavatum. Yet despite the advancement in the surgical techniques, it is still associated with various complications including bar displacement leading to reoperation. To overcome this problem, we developed the double compression and complete fixation-double bar (DCCF) system which consists of two metal bars that are inserted above and below the sternum and compressed to correct pectus excavatum. METHODS: Patients who underwent pectus excavatum correction surgery at this center between April 2006 and March 2017 were divided into the DCCF system group and the conventional Nuss procedure group and their demographic, clinical and surgical characteristics were compared. RESULTS: A total of 220 underwent DCCF system procedure, and 306 patients underwent conventional Nuss procedure. The DCCF system group had significantly shorter operation time (p
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research

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In this study, we reported a dual HDAC and DNMT inhibitor 208 and found it induced G1 cell cycle arrest and apoptosis in U937 cells. Proteome and bioinformatic analyses revealed that the combined inhibition of DNMT1 and HDAC by 208 affected the expression of a series of proteins involved in many biological processes. We observed that several proteins associated with G1 cell cycle arrest and apoptosis were down regulated after 208 treatment, including p85α, MEK, and CDK4, suggesting that 208 induces cell cycle arrest and apoptosis through the p85α/MEK-mediated pathway in U937 cells. Moreover, biological function...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 22 March 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Paula L.V. Lima, Claudia V. Pereira, Nadee Nissanka, Tania Arguello, Giulio Gavini, Carlos Magno da Costa Maranduba, Francisca Diaz, Carlos T. MoraesAbstractPhotobiomodulation (PBM) therapy is based on the use of specific light parameters to promote tissue repair. Although demonstrated in different cell models and tissues, the mechanism by which photobiomodulation operates is not well understood. Previous studies suggested that the cell proliferation enhancement triggered by red and near-infrared PBM invo...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
The objective of this study was to verify the relationship between metachronous contralateral inguinal hernia (MCIH) and CPPV, and the risk factors of MCIH.MethodsChildren with unilateral inguinal hernia from three medical centers underwent either open or laparoscopic repairs. Clinical information, including demographics, morphological characteristics of CPPV, follow-up outcomes were collected.ResultsAmong 2942 patients (92.2%) who received open repair with successful follow-up, 185 (6.29%) developed MCIHs [125 (10.9%) on the right side and 60 (3.3%)] on the left including 156 (7.07%) younger than 3 years old and 29 (3.94%...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
CONCLUSION: Additional genetic disorders are more frequent in those with omphalocele cases, and they are more frequently terminated during gestation that the gastroschisis fetuses. PMID: 30892123 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Conclusion: The use of bioprosthetic plugs to treat patients with complex anal fistulae seems to be a safe, viable option for complex fistula repair when other surgical attempts have failed. However, it should not be the treatment of choice. Further prospective randomized studies with a sufficient sample-size and standardized measurements are necessary to evaluate the efficacy of fistula plugs fully. PMID: 30889947 [PubMed - as supplied by publisher]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Authors: de Miranda JR, Choi IGG, Moreira MS, Martins MD, Cortes ARG, Yoshimoto M Abstract PURPOSE: This histologic study aimed at assessing bone healing after treatment with simvastatin in association with low-level laser therapy (LLLT). METHODS: Twenty-four male rats (Wistar) were submitted to surgery to create a bone defect of 5 mm in diameter in the parietal bone. These rats were randomly and equally divided into four treatment groups (n = 6): control (C), in which no treatment was performed; simvastatin (SIM), in which rats received daily subcutaneous doses of 2.5 mg/kg of simvastatin; LLLT, which was dail...
Source: International Journal of Oral and Maxillofacial Implants - Category: ENT & OMF Tags: Int J Oral Maxillofac Implants Source Type: research
"Lots of major brands have weathered some kind of crisis and have been able to recover. The public moves on pretty quickly. And soon enough, there will be some new crisis on people's minds."
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
ConclusionIntermediate results shows that this technique provides enhanced stability and improved functional outcome. But more prospective and randomised controlled studies with long term followup are required to confirm its role in prevention of hip dislocations.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Condition:   Rotator Cuff Injury Interventions:   Other: single row repair technique;   Other: double row repair technique Sponsor:   University Hospital, Basel, Switzerland Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionOur study offers pharmacological evidence on the folkloric use of A. vulgaris in wound treatment, particularly after incorporation into hydrogel, and underlines an importance of a proper vehicle for incorporation of herbal extracts intended for topical treatment.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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