Prevalence and risk factors of antibodies to human leukocyte antigens in haploidentical stem cell transplantation candidates: A multi-center study.

Prevalence and risk factors of antibodies to human leukocyte antigens in haploidentical stem cell transplantation candidates: A multi-center study. Hum Immunol. 2018 Jun 08;: Authors: Huo MR, Xu YJ, Zhai SZ, Lv M, Wang Y, Cao LQ, Xu LP, Zhang XH, Chen H, Chen YH, Wang FR, Han W, Sun YQ, Yan CH, Tang FF, Mo XD, Zhao MF, Liu KY, Huang XJ, Chang YJ Abstract We investigated the prevalence of and risk factors for antibodies to HLA in 1,663 haploidentical transplant candidates. Among these cases, 349 (21.0%) showed positive panel-reactive antibody (PRA) either for class I or class II HLA. Multivariate analysis showed the following: i) risk factors associated with the prevalence of PRA either for class I or class II HLA were female gender (P=0.018), prior transfusions (P<0.001) or pregnancy (P<0.001), and cases with MDS (P=0.018); compared to other patients, subjects with ALL had a lower prevalence of class I antibodies (P=0.017); and ii) risk factors associated with the prevalence of PRA both for class I and class II HLA were female gender (P=0.014), prior transfusions (P=0.003), previous pregnancy (P<0.001), and diagnosis with MDS (P=0.035). The percentages of antibodies against different antigens coded by the different HLA loci, including HLA-A, -B, -C, -DP, -DQ, and -DR, among all cases were 15.6%, 17.3%, 10.5%, 5.6%, 8.5%, and 9.7%, respectively. Risk factors associated with specific antibodies against HLA-A, -B, -C, -DP, -DQ,...
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research