Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia

This study assessed genetic contributions to six cognitive domains, identified by the MATRICS Cognitive Consensus Battery as relevant for schizophrenia, cognition-enhancing, clinical trials. Psychiatric Genomics Consortium Schizophrenia polygenic risk scores showed significant negative correlations with each cognitive domain. Genome-wide association analyses identified loci associated with attention/vigilance (rs830786 within HNF4G), verbal memory (rs67017972 near NDUFS4), and reasoning/problem solving (rs76872642 within HDAC9).

Source: Schizophrenia Research - June 12, 2018 Category: Psychiatry Authors: Soichiro Nakahara, Sarah Medland, Jessica A. Turner, Vince D. Calhoun, Kelvin O. Lim, Bryon A. Mueller, Juan R. Bustillo, Daniel S. O'Leary, Jatin G. Vaidya, Sarah McEwen, James Voyvodic, Aysenil Belger, Daniel H. Mathalon, Judith M. Ford, Guia Guffanti, Source Type: research