Doxycycline counteracts neuroinflammation restoring memory in Alzheimer ’s disease mouse models

β-amyloid oligomers (AβOs) and neuroinflammation are two main culprits to counteract in Alzheimer’s disease (AD). Doxycycline (DOXY) is a second generation antibiotic of the tetracycline class which are promising drugs tested in many clinical trials for a number of different pathologies. DOXY is endowed with anti-amyloidogenic properties and better crosses the blood-brain barrier, but its efficacy has never been tested in AD mice. We herein show that 15-16 months old APP/PS1dE9 (APP/PS1) AD mice receiving DOXY under different treatment regimens recovered their memory without plaque reducti on.

Source: Neurobiology of Aging - June 12, 2018 Category: Neuroscience Authors: Claudia Balducci, Giulia Santamaria, Pietro La Vitola, Edoardo Brandi, Federica Grandi, Arturo Roberto Viscomi, Marten Beeg, Marco Gobbi, Mario Salmona, Simone Ottonello, Gianluigi Forloni Source Type: research