Women have stronger hearts: Men are 64% more likely to die from a common cardiovascular condition

Researchers from Imperial College London found dilated cardiomyopathy causes fewer fatalities in women despite them being 10 per cent more at risk of heart failure and symptoms like fatigue.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Abstract Dilated cardiomyopathy (DCM) is the most common cause of heart failure (HF) in children, resulting in high mortality and need for heart transplantation. The pathophysiology underlying pediatric DCM is largely unclear, however there is emerging evidence that molecular adaptations and response to conventional HF medications differ between children and adults. In order to gain insight into alterations leading to systolic dysfunction in pediatric DCM, we measured cardiomyocyte contractile properties and sarcomeric protein phosphorylation in explanted pediatric DCM myocardium (N=8) compared to non-failing (NF)...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
We present a retrospective review of 13 consecutive children who underwent implantation of VAD between 2001 and 2018 in our center. The median age was 12  years (1–17 years), weight was 45 kg (10–82 kg). Etiologies of heart failure were dilated cardiomyopathy (CMP) (n = 8), myocarditis (n = 2), ischemic CMP (n = 1), restrictive CMP (n = 1) and congenital heart disease (n = 1). Pre-implantation ECMO was used in 5, mechanical ventilation in 4, renal replacement therapy in 2 and IABP in 1. Devices used were: Berlin Heart EXCO...
Source: Journal of Artificial Organs - Category: Transplant Surgery Source Type: research
ConclusionsWe describe a unique and novel cellular model that provides insight into the mitochondrial abnormalities present in DCMA and identifies SS-31 as a potential therapeutic for this devastating disease.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Nature Reviews Cardiology, Published online: 11 October 2019; doi:10.1038/s41569-019-0284-0In this Review, Rosenbaum and colleagues give a broad perspective on the genetic causes of dilated cardiomyopathy to provide a context for a discussion of the pragmatic use of genetic testing in heart failure clinics for patients presenting with new-onset dilated cardiomyopathy.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research
Publication date: Available online 7 October 2019Source: Journal of Cardiology CasesAuthor(s): Genzou Takemura, Kenji Onoue, Takanori Arimoto, Tetsu Watanabe, Akiko Tsujimoto, Chihiro Takada, Hideshi Okada, Tomoya Nakano, Yasuhiro Sakaguchi, Nagisa Miyazaki, Takatomo Watanabe, Hiromitsu Kanamori, Shinji Ogura, Yoshihiko Saito, Takako Fujiwara, Hisayoshi Fujiwara, Yasuaki HottaAbstractWe encountered an unfamiliar finding during electron microscopic examination of an endomyocardial biopsy obtained from a 55-year-old woman suffering from heart failure due to dilated phase hypertrophic cardiomyopathy. Many cardiomyocytes conta...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
In conclusion, AF seems to have a higher prevalence in the general population than previously thought, and is mostly associa ted with hypertension, cardiomyopathy and rheumatic heart disease in SSA. It is associated with a high incidence of heart failure and stroke. The management of AF is suboptimal in SSA, especially with a low uptake of oral anticoagulation.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: COMPREHENSIVE REVIEWS Source Type: research
Conclusions: We report the identification of a novel mutation in RBM20 by WES in a large pedigree with DCM. PMID: 31583969 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
We present a 26-year-old woman with an inotrope dependent severe dilated cardiomyopathy potentially caused by chronic ingestion of ED. The extensive investigation, consisting of cardiac magnetic resonance, F-18-fluorodesoxyglucose-positron emission tomography, coronary angiography and endomyocardial biopsy, was normal. A left ventricular assist device (LVAD) was implanted as a potential bridge to recovery. After 10 months of mechanical support and pharmacological treatment, cardiac function was recovered, and the LVAD was successfully explanted. This is the first case report of ED abuse leading to severe heart failure requ...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Conclusions: The canine model of CCC mimics human disease, reproducing the percentage of individuals that develop heart failure during the chronic infection. It is thus mandatory to establish inclusion criteria in the experimental design of canine preclinical studies to account for the variable effect that chronic infection has on systolic function.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
This study investigated whether targeted blood and urine metabolomics reflects disease severity in non-ischemic dilated cardiomyopathy (DCM) patients and compared its incremental value on top of NT-proBNP.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Original article Source Type: research
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