Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes [Medical Sciences]

Xerostomia (dry mouth) is the most common side effect of radiation therapy in patients with head and neck cancer and causes difficulty speaking and swallowing. Since aldehyde dehydrogenase 3A1 (ALDH3A1) is highly expressed in mouse salivary stem/progenitor cells (SSPCs), we sought to determine the role of ALDH3A1 in SSPCs using...

Source: Proceedings of the National Academy of Sciences - June 12, 2018 Category: Science Authors: Julie P. Saiki, Hongbin Cao, Lauren D. Van Wassenhove, Vignesh Viswanathan, Joshua Bloomstein, Dhanya K. Nambiar, Aaron J. Mattingly, Dadi Jiang, Che-Hong Chen, Matthew C. Stevens, Amanda L. Simmons, Hyun Shin Park, Rie von Eyben, Eric T. Kool, Davud Sirj Tags: Biological Sciences Source Type: research