NIH initiative aims to tackle opioid misuse, addiction, enhance pain management

(JAMA Network) In the   JAMA Viewpoint, 'Helping to End Addiction Over the Long-Term: The Research Plan for the NIH HEAL Initiative,' National Institutes of Health Director   Francis S. Collins, M.D., Ph.D., and coauthors discuss an interdisciplinary program aimed at advancing addiction and pain research in the United States to improve treatments for opioid misuse and addiction and to enhance pain management.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Theranica Bio-Electronics said yesterday that it raised a $35 million Series B round for the Nerivio Migra neurostim patch it’s developing to treat migraine headache. Netanya, Israel-based Theranica said VC shop aMoon led the round, joined by all of its existing backers, Lightspeed Venture Partners, LionBird, Corundum Open Innovation and Takoa. The company raised an unspecified amount in its seed round back in September 2016. Theranica closed out a nearly 300-patient pivotal study last October it used to back a bid for FDA clearance that met its primary endpoint and showed “high efficacy, safety and tolerabilit...
Source: Mass Device - Category: Medical Devices Authors: Tags: Featured Funding Roundup Neuromodulation/Neurostimulation Pain Management Wall Street Beat Theranica Bio-Electronics Source Type: news
Publication date: Available online 16 March 2019Source: PeptidesAuthor(s): Lori N. Eidson, Anne Z. MurphyAbstractEach year, over 50 million Americans suffer from persistent pain, including debilitating headaches, joint pain, and severe back pain. Although morphine is amongst the most effective analgesics available for the management of severe pain, prolonged morphine treatment results in decreased analgesic efficacy (i.e., tolerance). Despite significant headway in the field, the mechanisms underlying the development of morphine tolerance are not well understood. The midbrain ventrolateral periaqueductal gray (vlPAG) is a ...
Source: Peptides - Category: Biochemistry Source Type: research
CONCLUSIONS: Contrary to study expectations, higher opioid dose was associated with less DD. These findings call for prospective research to further elucidate the relationships between DD and other measures of impulsivity and prescription opioid doses. PMID: 30855719 [PubMed - in process]
Source: Journal of Opioid Management - Category: Addiction Tags: J Opioid Manag Source Type: research
Mar 13, 2019. . Sponsored by Mountain Plains Addiction Technology Transfer Center Network (HHS Region 8), University of North Dakota Center for Rural Health, University of North Dakota School of Medicine&Health Sciences
Source: Rural events via the Rural Assistance Center - Category: Rural Health Source Type: events
Source: Substance Abuse - Category: Addiction Authors: Source Type: research
Authors: Gabriel RA, Swisher MW, Sztain JF, Furnish TJ, Ilfeld BM, Said ET Abstract INTRODUCTION: There are various important implications associated with poorly controlled postoperative pain in the adult surgical patient - this includes cardiopulmonary complications, opioid-related side effects, unplanned hospital admissions, prolonged hospital stay, and the subsequent development of chronic pain or opioid addiction. With the ongoing national opioid crisis, it is imperative that perioperative providers implement pathways for surgical patients that reduce opioid requirements and pain-related complications. Areas co...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: June 2019Source: Materials Science and Engineering: C, Volume 99Author(s): R. Giannetti, G.A. Abraham, G. RiveroAbstractTramadol is an analgesic usually prescribed for the management of pain, with a certain risk of addiction in chronic patients. The incorporation of tramadol in sustained-release systems results particularly attractive for the administration of accurate doses. In this work, emulsion electrospinning was used for the preparation of tramadol-loaded nanofibrous membranes based on poly(ε-caprolactone). Compositional and processing parameters were screened and evaluated in terms of the m...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
This study and literature review were carried out to investigate whether oxycodone is the most addictive prescription opioid.Recent FindingsThis was a cross-sectional survey from a pain management practice in south-central Alaska and review of the literature involving 86 patients diagnosed with opioid dependence/opioid use disorder from 2013 to 2018. Patients were given a list of prescription opioids and asked to identify the one (1) most desirable to themselves, (2) most desirable among drug-using associates or community, and (3) they deemed most addictive. Patients with a history of heroin use were asked which, if any, s...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
CONCLUSIONS: Most stakeholders who completed the survey indicated that tramadol was essential to provide optimal pain management in the absence of access to strong opioids. PMID: 30782026 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
The cell phone blares out reveille. Your eyes open reluctantly and you realize it’s morning, having only gone to bed four hours earlier because of a late-night party. You creak out of bed to ready yourself for work, arthritic joints hurting much more than usual. A painful day lies ahead even after taking ibuprofen. Does this sound familiar? If it does, you are not alone. Nearly 70% of Americans report getting insufficient sleep on a regular basis, and approximately 20% of Americans suffer from chronic pain. Recently, the intersection between these two conditions has become more apparent. The association between sleep...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Fatigue Pain Management Sleep Source Type: blogs
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