Application of real-time three-dimensional contrast-enhanced ultrasound using SonoVue for the evaluation of focal liver lesions: a prospective single-center study.

This study aimed to investigate real-time three-dimensional CEUS (3D-CEUS) for evaluation of the vascular configuration of FLLs. Using real-time 3D-CEUS with SonoVue on 161 patients with FLLs, we found that when compared with 2D-CEUS, real-time 3D-CEUS provided more detailed information about the origin, continuity, and numbers and structures of the feeding artery. On 3D-CEUS hepatocellular carcinoma showed intratumoral vessels with diffuse enhancement, metastatic liver cancer showed peritumoral vessels or absence of tumor vessels with ring-like enhancement or non-enhancement, focal nodular hyperplasia showed a spoke-wheel artery with diffuse enhancement, and hemangiomas showed nodular enhancement. Our results demonstrate that real-time 3D-CEUS using SonoVue is an effective method for visualizing the characteristic vascular configuration of FLLs, and this may assist with the diagnosis. PMID: 29887960 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research

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ConclusionsThese observations suggest that SYD is effective in the enhancement of antioxidant ability via activation of Nrf2 pathway and the up-regulation of Nrf2-downstream phase II enzymes expression. The anti-inflammation and antioxidant action of SYD together contributes to the prevention and treatment of ulcerrelated colorectal cancer.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, a novel vitamin E succinate-based formulation of Ir (VES-Ir) combined with nanoscaled characteristics and synergistic combination was constructed through esterification. The conjugation makes amphiphilic VES-Ir prodrug self-assemble into nanoparticles with a fine diameter (VES-Ir NPs, 75.4 nm) of spherical morphology. Furthermore, VES-Ir NPs with a 1:1 drug-to-drug ratio was demonstrated to possess respectable physiological stability within 72 h test, while can react to pH/esterase-sensitive drug release in lysosomes internalized into tumor cells, potentially highlighting their alleviating side effects. Comp...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 22 January 2020Source: International Journal of PharmaceuticsAuthor(s): Tao Tan, Yuqi Wang, Hong Wang, Haiqiang Cao, Zhiwan Wang, Jing Wang, Jie Li, Yaping Li, Zhiwen Zhang, Siling Wang
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2020Source: Biomedicine &Pharmacotherapy, Volume 124Author(s): Danielle Kamato, Peter J. LittleAbstractThis review will cover the signalling pathways leading to the phosphorylation of the Smad linker region independent of Smad carboxy terminal phosphorylation. Characterising Smad linker region as a signalling pathway in its own right will encourage comprehensive signalling studies to provide solutions for successful discovery and exploitation of drug targets. The review describes Smad transcription factor signalling distinct from Transforming Growth Factor (TGF)-β signalling. Novel signalli...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Source: Expert Opinion on Drug Delivery - Category: Drugs & Pharmacology Authors: Source Type: research
Authors: Hou T, Fan Y, Dan W, Liu B, Wang Z, Zeng J, Li L Abstract Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in the pathway being strongly associated with disease. Recently, accumulating evidence has demonstrated a consistent increase in basal CMA activity in a wide array of cancer cell lines and human tumor biopsies, suggesting a potential link b...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
ConclusionsDespite the inherent bias of a retrospective analysis, our long-term results showed a low toxicity profile with a relatively low rate of biochemical control for HT re-treatment in patients affected by local radiorecurrent prostate cancer. Prospective trials are needed to investigate the role of EBRT in this setting.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Publication date: Available online 26 November 2019Source: Practical Radiation OncologyAuthor(s): Gabriela M. Alban, Daniela L. Buscariollo, Teresa Cheng, Jennifer Pretz, Betty Krechmer, Ivan Buzurovic, Lisa Singer, Martin King, Larissa LeeAbstractPurposeOur purpose was to evaluate outcomes and sites of failure for women with early stage endometrial adenocarcinoma treated with adjuvant high-dose-rate (HDR) vaginal brachytherapy (VB) with a low dose scheme.Methods and MaterialsRetrospective review identified 318 patients with International Federation of Gynecology and Obstetrics (FIGO) stage I-II endometrioid endometrial ca...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Authors: Schwartz JH, Ellison EC Abstract Preview Solid focal lesions of the liver can present numerous diagnostic challenges, and once diagnosis is made, careful decision making is needed to assure cost-effective management. In this article, the authors consider five solid lesions: hemangioma, focal nodular hyperplasia, liver cell adenoma, primary hepatocellular carcinoma, and metastatic cancer. Cystic lesions are assessed in a companion article on page 149. PMID: 29219688 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
​A previously healthy 17-year-old girl presented to the ED with one month of intermittent, burning epigastric pain associated with nausea and vomiting. Pain was worsened by spicy, greasy foods, and alleviated by sparkling water. She said she came to the ED because the pain had persisted for a while and was interfering with her life. The patient denied fevers, recent travel, or a change in bowel movements. She admitted to traveling to Nicaragua many times in her life and to an unintentional 20-pound weight gain over the past year.​Vitals at presentation were a heart rate of 83 bpm, temperature of 36.6°C, blood press...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
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