An atypical presentation of POEMS syndrome with IgG kappa type M protein and normal VEGF level: Case report and review of literature
We present an atypical case of POEMS syndrome with subclinical polyneuropathy, splenomegaly, hypogonadism, and myeloma of immunoglobulin G kappa type. The typical osteosclerotic lesions and skin lesions were absent, and vascular endothelial growth factor (VEGF) level was normal. Our patient also had chronic kidney disease due to focal segmental glomerulosclerosis. The patient died due to multisystem complications nine months after presenting with acute on chronic renal failure. POEMS syndrome is an uncommon, potentially fatal paraneoplastic syndrome presenting with plasma cell neoplasm and multisystem involvement. Despite the normal VEGF level, our patient was diagnosed to have possible POEMS syndrome due to other clinical manifestations. It may be reasonable to expand the diagnostic criteria of POEMS syndrome if further atypical cases are reported in the future.
ConclusionsOur results demonstrated that ddPCR could be used in detecting BRAF V600E mutation from FNA fluid samples with higher sensitivity and accuracy than ARMS.
CANCER symptoms cover a wide range of problems, some which may seem obvious while others are less so. Even simple things like a persistent cough, or frequent heartburn or indigestion could be a sign of some cancers, so it ’s important to monitor any changes to your body, no matter how small. If you suffer from heartburn or indigestion, here’s when to see a GP.
AbstractBladder cancer is currently considered the most common malignancy of the urinary tract. Thulium laser en bloc resection of bladder tumor (TmLRBT) and plasmakinetic transurethral resection of bladder tumor (PK-TURBT) are two alternative common procedures used in our department to manage patients with primary non-muscle invasive bladder cancer (NMIBC) over the past decade. In this work, the safety and efficacy of TmLRBT were retrospectively compared to those of PK-TURBT in patients with primary NMIBC. From January 2013 to December 2015, 256 patients diagnosed with primary NMIBC were selected for this retrospective st...
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8NJ06343E, PaperLin Ma, Wenjuan Gao, Xue Han, Fengli Qu, Lian Xia, Rong-Mei Kong Hyaluronidase (HAase) has been reported as a diagnostic and prognostic urinary biomarker for bladder cancer. Simple and sensitive methods capable of quantitative detection of HAase are desired for tumor diagnosis... The content of this RSS Feed (c) The Royal Society of Chemistry
Haiming Liu, Nan Wu, Zhe Zhang, XiaoDan Zhong, Hao Zhang, Hao Guo, Yongzhan Nie, Yuanning Liu
Patients receiving new kidneys and livers must take damaging anti-rejection drugs for the rest of their lives. Now researchers hope to train the immune system instead of just tamping it down.
Arteriovenous fistulas created in patients with chronic kidney disease often lose patency and fail to become usable. This prospective trial evaluated the efficacy of vonapanitase, a recombinant human elastase, in promoting radiocephalic fistula patency and use for hemodialysis.
We report the case of a 60-year-old female with a history of chronic low back and legs pain secondary to L4 and L5 laminectomies posterior arthrodesis and fusion.
This study aimed at exploring the effects of tDCS on negative emotion regulation as it pertains to ADHD related symptoms, which could potentially provide support for the use of the tDCS as an alternative treatment for ADHD.
Vagal nerve stimulation is gaining recognition as an important therapeutic approach especially for non-communicable diseases such as cardiovascular disease (CVD), Depression, Fibromyalgia, Arthritis, Type 2 Diabetes, Alzheimer, and certain types of cancer. In turn, decreased vagal tone its implicated in the prognosis of a wide range of diseases. Afferent vagal stimulation seems to have the key to reset certain pathophysiological states of the body leading to health improvement by reshaping neural networks.