Temple scientists eradicate cancer cells through dual targeting of DNA repair mechanisms

(Temple University Health System) BRCA proteins serve a critical role in cellular DNA repair, but when mutated they allow genetic error replication, facilitating cancer development. If the repair system is disabled in cancer cells, they use backup repair mechanisms and adapt to alternative repair pathways, a survival mode that underlies their ability to evade targeted drug therapies.Now, Temple scientists show it's possible to eliminate at least two backup repair mechanisms at the same time using two targeted therapies.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news