An Overview of the Loading Efficacy of Cationic Lipids with Milk Proteins:A Potential Application for Lipid Delivery.

An Overview of the Loading Efficacy of Cationic Lipids with Milk Proteins:A Potential Application for Lipid Delivery.
Curr Med Chem. 2018 Jun 08;:
Authors: Chanphai P, Bourassa P, Tajmir-Riahi HA
Abstract
In this review, the loading efficacies of helper and cationic lipids cholesterol (CHOL), 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), dioctadecyldimethyl-ammoniumbromide (DDAB) and dioleoylphosphatidylethanolamine (DOPE) with milk β-lactoglobulin, α-casein and β-casein were compared in aqueous solution at physiological conditions. Structural analysis showed that lipids bind milk proteins via hydrophilic, hydrophobic and H-bonding contacts with DOTAP and DDAB forming more stable protein conjugates. Loading efficacy was 30-50% and enhanced with cationic lipids. Lipid conjugation altered protein conformation, causing a partial protein structural destabilization. Milk proteins are capable of transporting lipids in vitro.
PMID: 29886822 [PubMed - as supplied by publisher]

Source: Current Medicinal Chemistry - June 8, 2018 Category: Chemistry Authors: Chanphai P, Bourassa P, Tajmir-Riahi HA Tags: Curr Med Chem Source Type: research