Australian guideline developers join forces to advance Living Evidence

This news item was orginally posted on Cochrane Australia website.A new report published heralds an exciting development for evidence-based health care in Australia, with the promise of near real-time incorporation of research into evidence-based guideline recommendations now a step closer to reality. TheLiving Evidence for Australian Health Care report details the outcomes of forum hosted byCochrane Australia last month  which brought together leading experts in evidence synthesis and guideline development across several of Australia’s most pressing chronic diseases to explore opportunities for advancing ‘Living’ models of systematic review and guideline production.Over the last five years, Cochrane and a number of Australian and international  partners have developed the foundations of the Living Evidence model of evidence synthesis and dissemination. This world-leading approach harnesses innovations in data systems, machine learning and citizen science to enable near real-time updating of systematic reviews, evidence-based guideline recommendations and other evidence products. Importantly, the Living Evidence model fast-tracks evidence synthesis without  compromising the rigorous, gold standard methods for systematic review that are needed to provide trustworthy recommendations about what works best in health based on the all of the evidence generated to date.In what...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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The open access study noted here is one of many to show that greater levels of physical activity correlate well with a reduced risk of age-related disease. It isn't possibly to reliably live to extreme old age on the back of a good exercise program, but that physical activity does reliably improve the odds of experiencing better rather than worse health in later life. Even small benefits can be worth chasing when they cost little and are reliably obtained, so long as that pursuit doesn't distract from far more important initiatives. Exercise is beneficial, but it is no substitute for the rejuvenation therapies presently un...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusions: The literature suggests that cumulative childhood adversity is modestly related to adult cardiometabolic disease, with effects somewhat stronger for CVD clinical outcomes. The absence of a consistent operational and conceptual definition of adversity and paucity of prospective designs temper the conclusions. It is time for further evaluation of the types and timing of childhood events that have maximal impact on adult cardiometabolic disease. (PsycINFO Database Record (c) 2018 APA, all rights reserved)
Source: Health Psychology - Category: Psychiatry & Psychology Source Type: research
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Martin Steinhoff, Martin Schmelz, Imre Lőrinc Szabó, Anne Louise OaklanderSummaryUnlike conventional itch, neuropathic itch develops in normal skin from excess peripheral firing or dampened central inhibition of itch pathway neurons. Neuropathic itch is a symptom of the same central and peripheral nervous system disorders that cause neuropathic pain, such as sensory polyneuropathy, radiculopathy, herpes zoster, stroke, or multiple sclerosis, and lesion location affects symptoms more than aetiology. The causes of neuropathic itch...
Source: The Lancet Neurology - Category: Neurology Source Type: research
CONCLUSIONS: Pilates should be considered for patients with NCDs, as it improves exercise tolerance. Future studies with robust methodologies are still needed to clarify its effectiveness on outcomes with moderate, limited or conflicting evidence and to establish the most suitable intervention protocol. PMID: 30012382 [PubMed - in process]
Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
This study aims to determine methodological variations in the event simulation approaches of published health economic decision models, in the field of obesity, and to investigate whether their predictiveness and validity were investigated via external event validation techniques, which investigate how well the model reproduces reality. Areas covered: A systematic review identified a total of 87 relevant papers, of which 72 that simulated obesity-associated events were included. Most frequently simulated events were coronary heart disease (≈83%), type 2 diabetes (≈74%), and stroke (≈66%). Only for ten pub...
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
Publication date: Available online 17 July 2018Source: The LancetAuthor(s): Peter M Rothwell, Nancy R Cook, J Michael Gaziano, Jacqueline F Price, Jill F F Belch, Maria Carla Roncaglioni, Takeshi Morimoto, Ziyah MehtaSummaryBackgroundA one-dose-fits-all approach to use of aspirin has yielded only modest benefits in long-term prevention of cardiovascular events, possibly due to underdosing in patients of large body size and excess dosing in patients of small body size, which might also affect other outcomes.MethodsUsing individual patient data, we analysed the modifying effects of bodyweight (10 kg bands) and height (10 cm ...
Source: The Lancet - Category: General Medicine Source Type: research
Medic 534, staffed by a paramedic and EMT, is dispatched to a nursing home for a 78-year-old female in respiratory distress. On arrival, the crew finds the patient in a chair accompanied by two nurses and the administrator on call. The patient is in obvious distress showing fatigue and an increased work of breathing. She is alert to voice, but diaphoretic, lethargic, and unable to speak due to rapid, shallow breathing. A nurse is administering a nebulizer containing 3 mL of albuterol sulfate/ipratropium. A second nurse states that the patient has been in increasing distress for the last 45 minutes. The nurse also says that...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Airway & Respiratory Patient Care Source Type: news
Diabetic Medicine,Volume 35, Issue 8, Page 1027-1036, August 2018.
Source: Diabetic Medicine - Category: Endocrinology Authors: Source Type: research
This study evaluates how aortic stiffening relates to resting CBF and cerebrovascular reactivity (CVR) in older adults. Methods -Vanderbilt Memory &Aging Project participants free of clinical dementia, stroke, and heart failure were studied, including older adults with normal cognition (NC, n=155, 72±7, 59% male) or mild cognitive impairment (MCI, n=115, 73±7, 57% male). Aortic pulse wave velocity (PWV m/sec) was quantified from cardiac magnetic resonance. Resting CBF (mL/100g/min) and CVR (CBF response to hypercapnic normoxia stimulus) were quantified from pseudo-continuous arterial spin labeling MRI. Li...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Clinical Cardiology, EarlyView.
Source: Clinical Cardiology - Category: Cardiology Authors: Source Type: research
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